Process Raman FAQs: Applications, benefits & technical details

Explore frequently asked questions about the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer to discover how real-time Raman analysis enables process monitoring, optimization, and control across biopharma, pharmaceutical, oil & gas, power generation, chemicals, polymers and other industrial applications.

 

For more information or to learn how process Raman can improve your operations, contact us today. 


Process Raman overview

Process Raman spectroscopy is a real-time, in situ analytical technology used to monitor chemical composition and process conditions directly in manufacturing environments. It enables continuous measurement without the need for sampling. Analysis via process Raman technology supports improved process understanding, control, and optimization.


Analyzer overview

The MarqMetrix All-In-One Process Raman Analyzer is an integrated Raman platform designed for real-time process monitoring in industrial environments. It combines spectroscopy hardware, embedded computing, and advanced analytics into a single system, enabling rapid deployment and scalable implementation across a wide range of applications. The MarqMetrix All-In-One Process Raman Analyzer AIO X variant is certified for ATEX Zone 0 hazardous areas, NEC/CEC Class I, Division 1 (North America), and IECEx Zone 0 (international/Asia-Pacific) making it suitable for hazardous location applications.


Industries & applications

The MarqMetrix All-In-One Process Raman Analyzer is designed to serve the following vertical markets:

  • Upstream & downstream Biopharma
  • Downstream & midstream Oil & Gas
  • Power generation
  • Pharmaceutical (small molecule)
  • Chemical
  • Polymers
  • Industrial

 

The MarqMetrix All-In-One X Process Raman Analyzer serves hazardous location applications.


Benefits & differentiation

  • Real-time process insights in seconds to minutes
  • Factory calibration, with no additional hardware calibration required
  • Small footprint for easy scalability
  • Increased operational efficiency, with easy set up and deployment
  • Modular multiplex architecture delivers lower capital and operating expenditures
  • Industry-leading MarqMetrix BallProbe™ sampling optics, high quality with less failure rates

Unlike traditional Raman systems that require multiple components and complex integration, the MarqMetrix All-In-One Process Raman Analyzer offers a plug-and-play, field-deployable solution. Its modular multiplex architecture enables true real-time multiple measurement points, eliminating single points of failure.  Its simplified system design reduces downtime and total cost of ownership

Our unique modular multiplexing approach is a distributed, multi-point sensing architecture that uses compact, independent analyzers to collect real-time data. All modules connect to one software environment for centralized visualization and easier process control.


Process control & ROI

The MarqMetrix All-In-One Process Raman Analyzer delivers continuous, real-time data that can be integrated into control systems. By integrating with process control systems, users can leverage Raman insights directly in process automation, enabling faster decision-making and tighter control loops.

By enabling real-time insights, reducing sampling costs, and optimizing process efficiency, the MarqMetrix All-In-One Process Raman Analyzer helps customers improve yield, reduce downtime, and enhance product quality. Its modular multiplexing capability further reduces capital and operating expenses.


Deployment & support

The MarqMetrix All-In-One Process Raman Analyzer is designed for plug-and-play deployment with minimal infrastructure requirements. Its compact, integrated design reduces installation complexity.

The system is built for industrial robustness with minimal maintenance requirements. The analyzer is factory calibrated and does not require additional hardware calibration. Thermo Fisher provides comprehensive global support, including application development, model building, validation, preventative maintenance and other lifecycle services to ensure long-term performance.


Integration

Yes. The MarqMetrix All-In-One Process Raman Analyzer is part of a broader ecosystem and can be integrated with complementary technologies such as:

  • Thermo Scientific™ DynaDrive™ and HyPerforma™ bioreactor platforms for bioprocess applications
  • AutoFLEX™ Flow Computers for natural gas applications
  • Thermo Scientific™ Process Twin Screw Extruders for polymer compounding applications
  • Thermo Scientific™ Pharma Twin Screw Extruders for pharmaceutical hot melt extrusion (HME) applications

Getting started

Customers can engage with Thermo Fisher to evaluate feasibility, develop application models, and design a tailored solution. Please contact us here.


System components

The process Raman analyzer, a fiberhead with 3m fiberoptic cable, a sampling optic of choice, a wireless keyboard and mouse, a monitor, and laser safety glasses are all included.


Software & connectivity

The MarqMetrix All-In-One Process Raman Analyzer supports Eigenvector PLS_Toolbox® and, Eigenvector SOLO®, and Thermo Scientific™ TQ Analyst™ chemometrics software packages to provide quantitative and qualitative results in real-time.

The supported protocols are OPC-UA, Modbus TCP/IP, and REST API.


Compliance & certifications

Class 3B laser device reported to the FDA.

Yes, the Thermo Scientific™ Lykos™ PAT Software is 21 CRF 11 compliant.


Electrical requirements

The input voltage is 90-264 VAC, 50-60Hz. The operating voltage is 12VDC, 2A.


Laser & spectral performance

It is configurable from 35mW to 450mW, depending on the instrument variant.

The spectral range is 100–3250 cm-1 (wavenumbers).


Hazardous area suitability

Yes. The MarqMetrix All-In-One Process Raman Analyzer AIO X variant is certified for ATEX Zone 0 hazardous areas, NEC/CEC Class I, Division 1 (North America), and IECEx Zone 0 (international/Asia-Pacific). These certifications make it suitable for operation in a wide range of global hazardous environment applications.