Cell Therapy Bioprocessing Solutions

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Empowering confidence across your cell therapy process

Cell therapy developers face high-stakes challenges—scaling complex workflows, striving for consistency from research to commercialization, and complying with rigorous regulatory and safety expectations—all to administer therapies faster. Whether you’re engineering CAR-T cells or advancing adherent stem cell therapies, minimizing variability and risk is critical. Thermo Fisher Scientific aims to deliver integrated, high-quality solutions designed to support your every step—from reliable labware designed to protect your science, to robust analytics that offer actionable insights, to GMP-grade reagents and closed-system platforms that help streamline cell isolation and expansion. Discover how our tools can de-risk your cell therapy development, accelerate timelines, and support success at every stage.

Explore our cell activation, isolation and expansion solutions

Support your cell therapy workflow from isolation to scale-up with GMP-ready solutions like automated isolation, activation and expansion platforms, media and reagents. Designed to help improve consistency, viability, and scalability at every stage, these products give you the edge when it comes to your cell therapy process development.

Closed, automated cell therapy manufacturing solution

The CTS DynaCellect Magnetic Separation System is a closed, automated solution for cell isolation, activation, and bead removal in cell therapy workflows. Paired with purpose-built consumables, it delivers high purity, recovery, and viability.


 

Next-generation isolation platform technology

Gibco CTS Detachable Dynabeads CD3/CD28 is a next-generation platform technology that helps combine isolation and activation in one step. The key differentiator of this new platform is that it is the first to have an active release mechanism in the GMP space for clinical trials or commercial manufacturing.
 

AOF media for T cell manufacturing

The OpTmizer One Serum-Free Media is a novel animal origin–free formulation that can help improve process consistency and scalability while showing high cell viability, improved growth, and early memory T-cell phenotype. This medium simplifies preparation and delivers superior T-cell expansion, viability, and early memory phenotype.

Improved T cell expansion in stirred-tank bioreactors

Stirred-tank bioreactors offer key advantages over traditional systems, including improved scalability and process control. This study highlights a robust expansion process using CTS OpTmizer Pro SFM, demonstrating consistent T cell growth across bioreactor platforms.

Flexible and high purity isolation

CTS Detachable Dynabeads CD4 and CD8, used with the automated CTS DynaCellect Magnetic Separation System, offer a cGMP-compliant, scalable solution for high-purity T cell isolation. Performance evaluations demonstrated effective isolation of individual and combined T cell subsets.
 

DynaDrive Single-Use Bioreactor

The Thermo Scientific DynaDrive Single-Use Bioreactor (S.U.B.) can offer a scalable option for advancing allogeneic cell therapy processes, at the 50 L scale. The flexible operating range, and high-performance bags support consistent performance and help streamline process development.
 

Critical labware and process consumables

We supply a full range of essential consumables—including cell culture plastics, sterile bags, process liquids, and cell stacks—to support every stage of your cell therapy workflow.

Cell Factory Systems for Adherent Cell Therapy

Thermo Fisher Scientific’s Cell Factory systems offer a scalable, closed platform ideal for expanding adherent cells such as iPSCs and MSCs under controlled conditions. These systems support consistent, high-throughput cell growth.

Labtainer Bioprocess Containers

Thermo Fisher’s Labtainer Pro BPCs are single-use containers ideal for storing and transporting media, buffers, and cell suspensions in cell therapy workflows. Their ergonomic design and efficient drainage help maintain sterility and streamline processing.
 

Production Chemicals and Services

Reliable access to high-quality cGMP chemicals is critical for cell therapy success. We help manage supply chain complexity and reduce risk to accelerate development and manufacturing.
 

Gibco Process Liquids and Buffers

Get reliable, made-to-order buffer solutions tailored for your cell therapy workflows. Gibco Process Liquids are GMP-manufactured to help ensure high quality, batch-to-batch consistency, and on-time delivery—helping you stay focused on advancing your work.
 

Single-Use Containment Solutions

We offer a broad selection of single-use labware to support your cell therapy workflows. Nalgene production bottles and carboys provide storage in a variety of materials and volumes, backed by regulatory documentation to support smooth integration into GMP-compliant processes.
 

Planning for Success in Cell-Based Manufacturing

This whitepaper provides essential strategies for successful cell-based manufacturing, covering key aspects such as process optimization, regulatory compliance, and risk management. Gain insights to enhance your manufacturing efficiency and support maintenance of product quality.

Comprehensive in-process and QC analytics

Support the safety and consistency of your cell therapy products with robust in-process and quality testing solutions. From environmental monitoring and sterility assurance to mycoplasma detection and lentiviral titer quantification, our portfolio supports regulatory compliance and process control at every stage.

Cell Therapy Analytics Solutions

Thermo Fisher Scientific offers rapid, highly sensitive analytical solutions, like Applied Biosystems SEQ, to quantify impurities and detect contaminants in cell therapy workflows, with same-day results to support efficient development, manufacturing, and regulatory compliance.
 

Analytics Knowledge Hub

The Analytics Knowledge Hub is a dynamic and robust collection of digital resources and innovative solutions for your cell therapy testing needs. It offers a comprehensive range of tools, like webinars, articles, eBooks, and infographics, designed to support analytical testing throughout the cell therapy workflow.

Optimizing Contamination Control in Cell Therapy Manufacturing

This webinar covers contamination control in cell therapy, focusing on automated systems, bioprocess containers, and analytical assays for sterility and mycoplasma detection. Experts will discuss how integrating these solutions can enhance process efficiency and product quality.

Lentiviral scale-up and production for gene engineering

Lentiviral vector production can be an essential step in the development of gene-engineered cell therapies, enabling stable gene integration. High-quality vectors are critical, as their purity and potency directly affect transduction efficiency, safety, and therapeutic success. Find out more on lentiviral production options from Thermo Fisher below.

Production and clarification of lentiviral vectors at the 50L scale

As viral vector–based therapies expand, scalable manufacturing is crucial to meet clinical and commercial demands. This study demonstrates 50 L scale lentiviral production using the CTS LV-MAX System and compares two scalable clarification methods—depth filtration and single-use centrifugation.

Complete Lentiviral Vector Production System

The CTS LV-MAX Lentiviral Production System is a scalable, high-yield platform designed for efficient production of lentiviral vectors in suspension cell culture. It combines optimized media, reagents, and protocols to support clinical and commercial gene therapy applications.

On-Demand webinar: details into lentiviral culture scale-up

Join our webinar to learn how the CTS LV-MAX System scales from flasks to bioreactors, with insights on transfection, lentiviral clarification, and the advantages of Thermo Scientific S.U.B. technologies.

 

Explore More: Extended Support & Strategic Resources

Looking for support beyond the lab? Discover our library of regulatory insights, technical guides, and global market resources designed to help you advance your cell therapy program—wherever you are in the journey.

Regulatory support

Thermo Fisher Scientific's products are used by biopharmaceutical companies as raw materials for further manufacturing. Our professionals help advance programs to the next development stage and navigate regulatory agency interactions.



 

Products designed to enable clinical and commercial cell therapy manufacturing

The Gibco CTS portfolio offers GMP-manufactured, safety-tested products with regulatory documentation to support your transition from discovery to clinical and commercial manufacturing. Our solutions help streamline therapeutic development, minimize risk, and simplify quality system requirements.

On-Demand Event: Regulatory Outlook in Cell and Gene Therapy

Watch this on-demand digital event exploring how evolving regulations will shape the future of cell and gene therapies. Expert speakers share insights on FDA processes, regulatory challenges, and strategies for navigating this complex landscape.


 

Discovery to commercialization solutions

Thermo Fisher Scientific offers rapid, highly sensitive analytical solutions, like Applied Biosystems SEQ, to quantify impurities and detect contaminants in cell therapy workflows, with same-day results to support efficient development, manufacturing, and regulatory compliance.

Accelerate cell therapy development through collaboration

Our partnership program supports customers' clinical and commercial success by providing access to our expertise and collaboration centers for scalable, end-to-end workflows.

 

Looking for case studies and more content?

This webinar covers contamination control in cell therapy, focusing on automated systems, bioprocess containers, and analytical assays for sterility and mycoplasma detection. Experts will discuss how integrating these solutions can enhance process efficiency and product quality.

Additional bioprocessing resources

Discover areas where you can cut costs and gain efficiency using our integrated calculator.

Explore our collection of information and insights to support your drug development journey.

Learn, evaluate, connect.


 

Connect with a Bioprocessing representative or request more info.

For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.