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产品信息
PA5-50548
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:200-1:1,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide corresponding to residues near the C terminal of human Ankyrin repeat domain 28 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
2.1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2636001 |
产品详细信息
The antibody detects endogenous levels of total ANKRD28 protein.
靶标信息
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. ANKRD28 selectively regulated phosphorylation of hnRNP-K at ser284, an effect that was enhanced in vivo by an S1013A/S1017A double mutant, suggesting that ANKRD28 targets PP1 in a regulated manner to dephosphorylate hnRNP-K selectively at ser284.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ankyrin repeat domain-containing protein 28; phosphatase interactor targeting K protein; Phosphatase interactor targeting protein hnRNP K; PITK; PP6-ARS-A; protein phosphatase 1, regulatory subunit 65; protein phosphatase 6 ankyrin repeat subunit A; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A; serine/threonine-protein phosphatase 6 regulatory subunit ARS-A
基因别名: AI465466; AI604979; ANKRD28; E430019N21Rik; KIAA0379; mKIAA0379; PITK; PPP1R65
UniProt ID: (Human) O15084, (Mouse) Q505D1
Entrez Gene ID: (Human) 23243, (Mouse) 105522
分子生物学功能:
scaffold/adaptor protein
