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Antibodies Inc
Ataxin-1/WT Monoclonal Antibody (N65/37), FL650
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产品信息
75-102-FL650
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N65/37
抗原
Synthetic peptide amino acids 746-761 of mouse ataxin-1 (accession number P54254).
偶联物
激发/发射光谱
655/676 nm
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: RKRRRWSAPE TRKLEK
靶标信息
Ataxin-1 (ATXN1) is a protein encoded by the ATXN1 gene. It is primarily known for its association with spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disorder. The "WT" designation refers to the wild-type, or normal, form of the protein as opposed to mutant forms associated with disease. Ataxin-1 plays a critical role in maintaining normal neuronal function, and its dysregulation due to genetic mutations leads to severe neurodegenerative conditions. Research into Ataxin-1 continues to be vital for developing therapeutic approaches for these disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alternative ataxin1; Ataxin-1; spinocerebellar ataxia 1; spinocerebellar ataxia 1 homolog; Spinocerebellar ataxia type 1 protein; Spinocerebellar ataxia type 1 protein homolog
基因别名: 2900016G23Rik; ATX1; ATXN1; C85907; D6S504E; ENSMUSG00000074917; Gm10786; SCA1
UniProt ID: (Human) P54253, (Mouse) P54254, (Rat) Q63540
Entrez Gene ID: (Human) 6310, (Mouse) 20238, (Rat) 25049
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
adult locomotory behavior
visual learning
negative regulation of phosphorylation
negative regulation of insulin-like growth factor receptor signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
nuclear export
excitatory postsynaptic potential
positive regulation of glial cell proliferation
RNA processing
biological_process
