Product References
Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial.
Nature medicine
Cascone T,Leung CH,Weissferdt A,Pataer A,Carter BW,Godoy MCB,Feldman H,William WN,Xi Y,Basu S,Sun JJ,Yadav SS,Rojas Alvarez FR,Lee Y,Mishra AK,Chen L,Pradhan M,Guo H,Sinjab A,Zhou N,Negrao MV,Le X,Gay CM,Tsao AS,Byers LA,Altan M,Glisson BS,Fossella FV,Elamin YY,Blumenschein G,Zhang J,Skoulidis F,Wu J,Mehran RJ,Rice DC,Walsh GL,Hofstetter WL,Rajaram R,Antonoff MB,Fujimoto J,Solis LM,Parra ER,Haymaker C,Wistuba II,Swisher SG,Vaporciyan AA,Lin HY,Wang J,Gibbons DL,Jack Lee J,Ajami NJ,Wargo JA,Allison JP,Sharma P,Kadara H,Heymach JV,Sepesi B
12-2239-42 was used in Flow cytometry/Cell sorting to report the results and correlates of two arms of the phase 2 platform NEOSTAR trial testing neoadjuvant Nivo+CT and Ipi+Nivo+CT with major pathologic response (MPR) as the primary endpoint.
Wed Mar 01 00:00:00 EST 2023
GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity.
Cancer cell
Heitzeneder S,Bosse KR,Zhu Z,Zhelev D,Majzner RG,Radosevich MT,Dhingra S,Sotillo E,Buongervino S,Pascual-Pasto G,Garrigan E,Xu P,Huang J,Salzer B,Delaidelli A,Raman S,Cui H,Martinez B,Bornheimer SJ,Sahaf B,Alag A,Fetahu IS,Hasselblatt M,Parker KR,Anbunathan H,Hwang J,Huang M,Sakamoto K,Lacayo NJ,Klysz DD,Theruvath J,Vilches-Moure JG,Satpathy AT,Chang HY,Lehner M,Taschner-Mandl S,Julien JP,Sorensen PH,Dimitrov DS,Maris JM,Mackall CL
12-2239-42 was used in Flow cytometry/Cell sorting to highlight the critical interplay between CAR design and antigen density threshold, demonstrate potent efficacy and safety of a lead GPC2-CAR candidate suitable for clinical testing, and credential oncofetal antigens as a promising class of targets for CAR T cell therapy of solid tumors.
Mon Jan 10 00:00:00 EST 2022
Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
Cell
Béziat V,Rapaport F,Hu J,Titeux M,Bonnet des Claustres M,Bourgey M,Griffin H,Bandet É,Ma CS,Sherkat R,Rokni-Zadeh H,Louis DM,Changi-Ashtiani M,Delmonte OM,Fukushima T,Habib T,Guennoun A,Khan T,Bender N,Rahman M,About F,Yang R,Rao G,Rouzaud C,Li J,Shearer D,Balogh K,Al Ali F,Ata M,Dabiri S,Momenilandi M,Nammour J,Alyanakian MA,Leruez-Ville M,Guenat D,Materna M,Marcot L,Vladikine N,Soret C,Vahidnezhad H,Youssefian L,Saeidian AH,Uitto J,Catherinot É,Navabi SS,Zarhrate M,Woodley DT,Jeljeli M,Abraham T,Belkaya S,Lorenzo L,Rosain J,Bayat M,Lanternier F,Lortholary O,Zakavi F,Gros P,Orth G,Abel L,Prétet JL,Fraitag S,Jouanguy E,Davis MM,Tangye SG,Notarangelo LD,Marr N,Waterboer T,Langlais D,Doorbar J,Hovnanian A,Christensen N,Bossuyt X,Shahrooei M,Casanova JL
12-2239-42 was used in Flow cytometry/Cell sorting to conclude that human CD28-dependent T cell responses are largely redundant for protective immunity.
Thu Jul 08 00:00:00 EDT 2021
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.
Cancer cell
Srivastava S,Furlan SN,Jaeger-Ruckstuhl CA,Sarvothama M,Berger C,Smythe KS,Garrison SM,Specht JM,Lee SM,Amezquita RA,Voillet V,Muhunthan V,Yechan-Gunja S,Pillai SPS,Rader C,Houghton AM,Pierce RH,Gottardo R,Maloney DG,Riddell SR
12-2239-42 was used in Flow Cytometry to test strategies for enhancing efficacy of CAR-T cells targeting the tumor-associated antigen receptor tyrosine kinase-like orphan receptor 1 (ROR1) infiltrating tumors.
Mon Feb 08 00:00:00 EST 2021
Neoadjuvant Chemotherapy Increases Cytotoxic T Cell, Tissue Resident Memory T Cell, and B Cell Infiltration in Resectable NSCLC.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Gaudreau PO,Negrao MV,Mitchell KG,Reuben A,Corsini EM,Li J,Karpinets TV,Wang Q,Diao L,Wang J,Federico L,Parra-Cuentas ER,Khairullah R,Behrens C,Correa AM,Gomez D,Little L,Gumbs C,Kadara HN,Fujimoto J,McGrail DJ,Vaporciyan AA,Swisher SG,Walsh G,Antonoff MB,Weissferdt A,Tran H,Roarty E,Haymaker C,Bernatchez C,Zhang J,Futreal PA,Wistuba II,Cascone T,Heymach JV,Sepesi B,Zhang J,Gibbons DL
12-2239 was used in Flow cytometry/Cell sorting to support that, in the context of resectable NSCLC, neoadjuvant chemotherapy promotes antitumor immunity through T and B cell recruitment in the IME and through a phenotypic change toward cytotoxic and memory CD8+ and CD4+ memory helper T cells.
Fri Jan 01 00:00:00 EST 2021
CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice.
Cell reports. Medicine
Li N,Torres MB,Spetz MR,Wang R,Peng L,Tian M,Dower CM,Nguyen R,Sun M,Tai CH,de Val N,Cachau R,Wu X,Hewitt SM,Kaplan RN,Khan J,St Croix B,Thiele CJ,Ho M
12-2239-42 was used in Flow cytometry/Cell sorting to investigate if RNA-seq data can be exploited to help identify tumor-associated exons that can be targeted by CAR T cell therapies.
Tue Jun 15 00:00:00 EDT 2021
MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals.
Viruses
Stunnenberg M,van Pul L,Sprokholt JK,van Dort KA,Gringhuis SI,Geijtenbeek TBH,Kootstra NA
12-2239 was used in Flow cytometry/Cell sorting to study the underlying mechanisms involved in the control of viral replication in individuals homozygous for this MAVS genotype.
Thu Jul 16 00:00:00 EDT 2020
Combined p14ARF and Interferon-β Gene Transfer to the Human Melanoma Cell Line SK-MEL-147 Promotes Oncolysis and Immune Activation.
Frontiers in immunology
Cerqueira OLD,Clavijo-Salomon MA,Cardoso EC,Citrangulo Tortelli Junior T,Mendonça SA,Barbuto JAM,Strauss BE
12-2239 was used in Flow cytometry/Cell sorting to demonstrate a development to an adenovirus-mediated gene therapy approach, resulting non oncolysis, immunogenic cel death and subsequent activation of immune cells in human melanoma cells.
Fri Jun 18 00:00:00 EDT 2021
Circulating Exosomes Inhibit B Cell Proliferation and Activity.
Cancers
Schroeder JC,Puntigam L,Hofmann L,Jeske SS,Beccard IJ,Doescher J,Laban S,Hoffmann TK,Brunner C,Theodoraki MN,Schuler PJ
12-2239 was used in Flow cytometry/Cell sorting to isolate and analyse peripheral B cells by flow cytometry to understand the effects of exosomes on B cells.
Wed Jul 29 00:00:00 EDT 2020
CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Majzner RG,Theruvath JL,Nellan A,Heitzeneder S,Cui Y,Mount CW,Rietberg SP,Linde MH,Xu P,Rota C,Sotillo E,Labanieh L,Lee DW,Orentas RJ,Dimitrov DS,Zhu Z,Croix BS,Delaidelli A,Sekunova A,Bonvini E,Mitra SS,Quezado MM,Majeti R,Monje M,Sorensen PHB,Maris JM,Mackall CL
12-2239-42 was used in Flow Cytometry to present B7-H3 (CD276) as a putative target for CAR T-cell therapy of pediatric solid tumors, including those arising in the central nervous system.
Mon Apr 15 00:00:00 EDT 2019
YY1 Upregulates Checkpoint Receptors and Downregulates Type I Cytokines in Exhausted, Chronically Stimulated Human T Cells.
iScience
Balkhi MY,Wittmann G,Xiong F,Junghans RP
12-2239 was used in Flow cytometry/Cell sorting to elucidate a Yin Yang-1-centred mechanism for diverse cellular components correlated with exhaustion.
Fri Apr 27 00:00:00 EDT 2018
PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells.
Frontiers in immunology
Stecher C,Battin C,Leitner J,Zettl M,Grabmeier-Pfistershammer K,Höller C,Zlabinger GJ,Steinberger P
12-2239 was used in Flow cytometry/Cell sorting to use human T cells stimulated with allogeneic dendritic cells were used to compare immune checkpoint inhibitors targeting TIM-3, BTLA, LAG-3, CTLA-4 and TIGIT alone or in combination with a PD-1 antibody.
Wed Mar 30 00:00:00 EDT 2022