Hamburger Menu Button
Thermo Fisher Scientific Logo
登录
没有账号?建立账号 注册
  • 产品
    • 抗体
    • 引物合成
    • GeneArt Gene Synthesis Instant Designer
    • TaqMan Assay and Array Search
    • PCR 设备和耗材
    • 色谱柱和纯化柱
    • 实验室离心机
    • 分子生物学试剂和试剂盒
    • 实验室塑料耗材及用品
    • 查看所有产品分类
  • 应用和技术
    • 色谱
    • 细胞转染和培养
    • 实时荧光定量PCR
    • 质谱
    • 实验室塑料耗材及用品
    • 电子显微镜
    • 蛋白质生物学
    • PCR
    • RNAi
    • 环境
    • 查看所有应用和技术
  • 服务
    • 定制服务
    • 企业级实验室信息化服务
    • 企业服务
    • 金融&租赁服务
    • 仪器服务
    • OEM和商业供应
    • 培训服务
    • 360° CDMO 和 CRO 服务
    • CDMO 服务
    • 临床试验 CRO 服务
    • 查看所有帮助和支持
  • 帮助和支持
    • 学习中心
    • 联系我们
    • 更改国家或地区
    • 查看所有帮助和支持
  • 热门产品
    • TaqMan Real-Time PCR Assays
      TaqMan 实时荧光定量 PCR 试剂盒
    • Antibodies
      抗体
    • Oligos, Primers & Probes
      寡核苷酸、引物、探针
    • GeneArt Gene Synthesis
      GeneArt 基因合成
    • Cell Culture Plastics
      细胞培养耗材
  • 联系我们
  • 货号直购
  • 订单查询
  • 查找文件&证书
Thermo Fisher Scientific Logo

Search Thermo Fisher Scientific

搜索全部或下列指定分类
Search button Close
          • 联系我们
          • 货号直购
          • 登录
            登录
            没有账号?建立账号 注册
            • 我的账号
            • 订单
            • 账单及发票查询
            • 定制产品及项目

          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • CD49b (Integrin alpha 2) Antibodies

          Invitrogen

          CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), FITC, eBioscience™

          8个已发表图片
          58 篇参考文献
          查看其他48个CD49b (Integrin alpha 2)抗体

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          说明书
          实验方案
          问题与答案
          技术支持
          说明书
          实验方案
          问题与答案
          技术支持

          Cite CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), FITC, eBioscience™

          • 抗体检测数据 (1)
          • 已发表图片 (8)
          CD49b (Integrin alpha 2) Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.
          CD49b (Integrin alpha 2) Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.

          图: 1 / 9

          {{ $ctrl.currentElement.advancedVerification.fullName }}
          {{ $ctrl.currentElement.advancedVerification.text }}

          CD49b (Integrin alpha 2) Antibody (11-5971-82) in Flow

          Staining of BALB/c splenocytes with Anti-Mouse NK1-1 APC (Product # 17-5941-82) and 0.25 µg of Rat IgM Isotype Control FITC (Product # 11-4341-82) (left) or 0.25 µg of Anti-Mouse CD49b (Integrin alpha 2) FITC (right). Total viable cells were used for analysis. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

          {{$ctrl.videoDesc}}

          {{$ctrl.videoLongDesc}}

          CD49b (Integrin alpha 2) Antibody in Flow Cytometry (Flow)
          CD49b (Integrin alpha 2) Antibody in Flow Cytometry (Flow)
          CD49b (Integrin alpha 2) Antibody in Flow Cytometry (Flow)
          CD49b (Integrin alpha 2) Antibody in Flow Cytometry (Flow)
          CD49b (Integrin alpha 2) Antibody in Flow Cytometry (Flow)
          CD49b (Integrin alpha 2) Antibody in Immunohistochemistry (IHC)
          CD49b (Integrin alpha 2) Antibody in Immunohistochemistry (IHC)
          CD49b (Integrin alpha 2) Antibody in Immunohistochemistry (IHC)
          CD49b (Integrin alpha 2) Antibody in Western Blot (WB)

          产品信息

          11-5971-82

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          -
          查看1篇已发表文章 1篇已发表文章

          免疫组化 (IHC)

          -
          查看3篇已发表文章 3篇已发表文章

          流式细胞分析 (Flow)

          0.5 µg/test
          查看52篇已发表文章 52篇已发表文章

          其他PubMed (Misc)

          -
          查看2篇已发表文章 2篇已发表文章
          产品规格

          种属反应

          Mouse

          已发表种属

          Mouse

          宿主/亚型

          Rat / IgM, kappa

          推荐的同型对照

          Rat IgM Isotype Control (eBRM), FITC, eBioscience™

          分类

          Monoclonal

          类型

          Antibody

          克隆号

          DX5

          偶联物

          FITC FITC FITC
          • Unconjugated
          • Alexa Fluor 700 
          • APC 
          • APC-eFluor 780
          • Biotin 
          • eFluor 450
          • eFluor 506
          • PE 
          • PE-Cyanine5
          • PE-Cyanine5.5
          • PE-Cyanine7
          • PE-eFluor 610
          • PerCP-eFluor 710
          • Request custom conjugation

          激发/发射光谱

          498/517 nm 查看光谱 spectra

          形式

          Liquid

          浓度

          0.5 mg/mL

          纯化类型

          Affinity chromatography

          保存液

          PBS, pH 7.2

          内含物

          0.09% sodium azide

          保存条件

          4°C, store in dark, DO NOT FREEZE!

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_465327

          产品详细信息

          Description: The DX5 monoclonal antibody reacts with CD49b, an antigen expressed on a majority of mouse natural killer cells and a subset of T cells. DX5 reacts with all strains of mouse tested including the most commonly used strains, BALB/c, C57BL/6, C3H, CBA, DBA, AKR, SJL and 129. Simultaneous staining of C57BL/6 spleen cells with anti-NK1.1 mAb (PK136) and DX5 reveals coexpression of both markers by a majority of cells as well as presence of small populations of DX5+PK136- and DX5-PK136+ cells.

          Applications Reported: The DX5 antibody has been reported for use in flow cytometric analysis.

          Applications Tested: The DX5 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

          Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

          Filtration: 0.2 µm post-manufacturing filtered.

          靶标信息

          CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          How to use the Panel Builder

          Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

          生物信息学

          蛋白别名: BDPLT9; CD49 antigen-like family member B; CD49b; Collagen receptor; GPIa; Integrin alpha-2; Platelet membrane glycoprotein Ia; VLA-2 receptor, alpha 2 subunit; VLA-2 subunit alpha; VLA2 receptor

          查看更多 收起

          基因别名: CD49B; DX5; Itga2

          查看更多 收起

          UniProt ID: (Mouse) Q62469

          查看更多 收起

          Entrez Gene ID: (Mouse) 16398

          查看更多 收起

          功能
          integrin binding collagen binding protein complex binding collagen receptor activity laminin binding metal ion binding protein heterodimerization activity collagen binding involved in cell-matrix adhesion integrin
          参与通路
          positive regulation of leukocyte migration substrate-dependent cell migration hypotonic response cell adhesion cell-matrix adhesion integrin-mediated signaling pathway positive regulation of epithelial cell migration positive regulation of alkaline phosphatase activity positive regulation of smooth muscle cell migration positive regulation of cell projection organization cell-substrate adhesion positive regulation of collagen biosynthetic process positive regulation of collagen binding cell adhesion mediated by integrin collagen-activated signaling pathway positive regulation of DNA binding skin morphogenesis establishment of protein localization positive regulation of translation positive regulation of cell adhesion positive regulation of smooth muscle contraction focal adhesion assembly positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response positive regulation of positive chemotaxis detection of mechanical stimulus involved in sensory perception of pain positive regulation of transmission of nerve impulse positive regulation of phagocytosis, engulfment
          It has to be done as per old AB suggested Products section.
          guarantee_icon

          性能保障

          只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符,您即可享受免费退换货服务。*

          了解更多
          help_icon

          随时为您服务

          获取常见问题的专家解答,或者直接联系我们的技术专家,咨询应用、设备、常规产品使用问题。

          联系技术支持
          订购 Plus Icon Minus Icon
          • 订单状态查询
          • 订单支持
          • 货号直购
          • 现货供应中心
          • 电子采购
          支持 Plus Icon Minus Icon
          • 帮助&支持
          • 联系我们 - 400 820 8982
          • 技术支持中心
          • 查找文件&证书
          • 报告网站问题
          资源 Plus Icon Minus Icon
          • 学习中心
          • 促销
          • 活动&研讨会
          • 社交媒体
          关于赛默飞 Plus Icon Minus Icon
          • 关于我们
          • 招聘
          • 投资者关系
          • 新闻
          • 社会责任
          • 商标
          品牌 Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Patheon
          • PPD
          • 服务条款
          • 隐私政策
          • 定价和运输保险政策
          © 2006-2025 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          China flag icon
          China
          本网站销售的所有产品均不得用于人类或动物之临床诊断或治疗,仅可用于工业或者科研等非医疗目的。
             电子营业执照 | 经营证照公示 | ICP备案号:沪ICP备11003924号 | 沪公网安备 31011502006935号

          Your items have has been added!


          Host server : magellan-search-green-56756dfb8b-mfpfg:80/100.66.79.199:80.
          git-commit: de6905f249d25e22729e613aef254bb544bd8b7c
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.31.1-2025.06.25-1.0