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产品信息
MA5-18146
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
流式细胞分析 (Flow) |
4 µLx100 µL whole blood or 10^6 cells | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Non-human primate |
宿主/亚型 |
Mouse / IgM |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
MEM-118 |
抗原 |
HPB-ALL human T cell line |
偶联物 |
Alexa Fluor™ 488
|
激发/发射光谱 |
499/520 nm
查看光谱
|
形式 |
Liquid |
纯化类型 |
Size-exclusion chromatography |
保存液 |
TBS, pH 8.0, with 0.2% BSA |
内含物 |
15mM sodium azide |
保存条件 |
4° C, store in dark, DO NOT FREEZE! |
RRID |
AB_2539520 |
产品详细信息
This antibody recognizes an epitope in the SCR4 domain of CD55.
靶标信息
CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathway of complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation and CD55 can regulate complement when bound to CD97. In tumors, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness and evasion of apoptosis. CD55 is a 70 kDa glycoprotein (in erythrocytes) anchored in the membrane by glycosylphosphatidylinositol tail. In other cells, the apparent molecular weight is somewhat larger for CD55 and has a substantial content of O-glycans. CD55 binds to activated C4b or C3b complement fragments on the cell surface, preventing the assembly and accelerating the decay of both classical and alternative pathways. CD55 carries the Cromer related blood group antigens. Two alternatively spliced transcripts encoding CD55 have been identified, and the predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. CD55 has been studied to have a role in prostate cancer growth and survival.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
Flow Cytometry
Panel Builder
How to use the Panel Builder
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生物信息学
蛋白别名: CD55; CD55 antigen; CD55 molecule, decay accelerating factor for complement (Cromer blood group); Complement decay-accelerating factor; RP11-357P18.1
基因别名: CD55; CR; CROM; DAF; TC
UniProt ID: (Human) P08174
Entrez Gene ID: (Human) 1604
ER to Golgi vesicle-mediated transport
complement activation, classical pathway
positive regulation of cytosolic calcium ion concentration
regulation of complement activation
regulation of lipopolysaccharide-mediated signaling pathway
CD4-positive, alpha-beta T cell cytokine production
innate immune response
respiratory burst
negative regulation of complement activation
viral entry into host cell
positive regulation of CD4-positive, alpha-beta T cell activation
positive regulation of CD4-positive, alpha-beta T cell proliferation
