Invitrogen

CGRP Monoclonal Antibody (5)

CGRP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 3

CGRP Antibody (ABS 026-05-02) in IHC (P)

Immunohistochemical analysis of CGRP alpha in paraffin-embedded rat tissue using a CGRP alpha monoclonal antibody (Product # ABS 026-05-02) after overnight incubation at a dilution of 1:400 in 1% BSA/PBS.

Product Image Gallery

产品信息

ABS 026-05-02

应用

建议稀释比

已发表文章

免疫组化 (IHC)

查看7篇已发表文章 7篇已发表文章

免疫组化（石蜡） (IHC (P))

Assay-dependent

查看1篇已发表文章 1篇已发表文章

酶联免疫吸附实验 (ELISA)

Assay-dependent

产品规格

种属反应

Human, Rat

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

抗原

Synthetic peptide corresponding to residues 19-37 of human alpha-CGRP.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.02 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

15mM sodium azide

保存条件

4°C, store in dark

运输条件

Ambient (domestic); Wet ice (international)

AB_1073000

产品详细信息

ABS 026-05-02 detects CGRP alpha in human and rat samples. ABS 026-05-02 binds human alpha-CGRP. Based on inhibition ELISA, this antibody shows full cross-reactivity with rat alpha-CGRP and about about 50% cross-reactivity with human beta-CGRP. Cross-reactivity with coated rat alpha-CGRP is low (8%) and there is no cross-reaction with human amylin.

ABS 026-05-02 has been successfully used in ELISA and immunohistochemistry procedures.

靶标信息

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

A putative anti-inflammatory role for TRPM8 in irritable bowel syndrome-An exploratory study.

Neurogastroenterology and motility

Peiris M,Weerts ZZRM,Aktar R,Masclee AAM,Blackshaw A,Keszthelyi D

ABS 026-05-02 was used in ELISA, Immunohistochemistry (Paraffin) to show that TRPM8 immunoreactivity is colocalized with immune cells predominantly of the dendritic cell lineage, in close approximation to nerve endings, and TRPM8 protein and mRNA expression was increased in IBS patients compared to controls (p < 0.001).

Wed Sep 01 00:00:00 UTC 2021

UEG Week 2020 Poster Presentations.

United European gastroenterology journal

No authors listed

ABS 026-05-02 was used in Immunohistochemistry to evaluate the role of serum adipokines as possible biomarkers in Crohn’s disease.

Thu Oct 01 00:00:00 UTC 2020

A novel role for the extracellular matrix glycoprotein-Tenascin-X in gastric function.

The Journal of physiology

Aktar R,Peiris M,Fikree A,Eaton S,Kritas S,Kentish SJ,Araujo EJA,Bacarin C,Page AJ,Voermans NC,Aziz Q,Blackshaw LA

ABS 026-05-02 was used in Immunohistochemistry to report the first role for TNX in gastric function which included the result of TNXB-defifient patients experiencing significantly greater symptoms of reflux, indigestion and abdominal pain.

Fri Mar 01 00:00:00 UTC 2019

Esophageal mucosal innervation in functional heartburn: Closer to healthy asymptomatic subjects than to non-erosive reflux disease patients.

Neurogastroenterology and motility

Nikaki K,Woodland P,Lee C,Ghisa M,Marinelli C,Savarino E,Sifrim D

ABS 026-05-02 was used in ELISA, Immunohistochemistry (Paraffin) to study the Esophageal mucosal innervation in functional heartburn.

Sun Sep 01 00:00:00 UTC 2019

The extracellular matrix glycoprotein tenascin-X regulates peripheral sensory and motor neurones.

The Journal of physiology

Aktar R,Peiris M,Fikree A,Cibert-Goton V,Walmsley M,Tough IR,Watanabe P,Araujo EJA,Mohammed SD,Delalande JM,Bulmer DC,Scott SM,Cox HM,Voermans NC,Aziz Q,Blackshaw LA

ABS 026-05-02 was used in Immunohistochemistry to study the effect of Tenascin-X on neural function.

Sat Sep 01 00:00:00 UTC 2018

Superficial Esophageal Mucosal Afferent Nerves May Contribute to Reflux Hypersensitivity in Nonerosive Reflux Disease.

Gastroenterology

Woodland P,Shen Ooi JL,Grassi F,Nikaki K,Lee C,Evans JA,Koukias N,Triantos C,McDonald SA,Peiris M,Aktar R,Blackshaw LA,Sifrim D

ABS 026-05-02 was used in Immunohistochemistry to study the distribution of mucosal nerve fibers in patients with nonerosive reflux disease, erosive reflux disease, and Barrett's esophagus, and compare the results with those of healthy subjects.

Wed Nov 01 00:00:00 UTC 2017

Distinct afferent innervation patterns within the human proximal and distal esophageal mucosa.

American journal of physiology. Gastrointestinal and liver physiology

Woodland P,Aktar R,Mthunzi E,Lee C,Peiris M,Preston SL,Blackshaw LA,Sifrim D

ABS 026-05-02 was used in immunohistochemistry - paraffin section to study mucosal barrier integrity and afferent nerve distribution in the proximal and distal esophagus of healthy human

Sun Mar 15 00:00:00 UTC 2015

Distinct afferent innervation patterns within the human proximal and distal esophageal mucosa.

American journal of physiology. Gastrointestinal and liver physiology

Woodland P,Aktar R,Mthunzi E,Lee C,Peiris M,Preston SL,Blackshaw LA,Sifrim D

ABS 026-05-02 was used in immunohistochemistry - paraffin section to study mucosal barrier integrity and afferent nerve distribution in the proximal and distal esophagus of healthy human

Sun Mar 15 00:00:00 UTC 2015

生物信息学

蛋白别名: Alpha-type CGRP; Calcitonin; calcitonin 1; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin-related polypeptide alpha; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; CGRP1; katacalcin; MGC126648; RAT calcitonin

查看更多收起

基因别名: Cal1; CAL6; Calc; CALC1; CALCA; calcitonin; CGRP; CGRP-I; CGRP1; CT; KC; PCT; RATCAL6

查看更多收起

UniProt ID: (Human) P06881, (Rat) P01256

查看更多收起

Entrez Gene ID: (Human) 796, (Rat) 24241

查看更多收起

功能

hormone activity protein binding calcitonin receptor binding identical protein binding receptor binding neuropeptide hormone activity protein complex binding peptide hormone

参与通路