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产品信息
PA5-50074
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:3,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthesized peptide derived from C-terminal of human CHRNA10. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2635527 |
产品详细信息
The antibody detects endogenous levels of total CHRNA10 protein.
靶标信息
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acetylcholine receptor; acetylcholine receptor, nicotinic, alpha 10 (neuronal); cholinergic receptor; cholinergic receptor, nicotinic alpha 10; cholinergic receptor, nicotinic, alpha 10 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 10; NACHR alpha-10; Neuronal acetylcholine receptor subunit alpha-10; Nicotinic acetylcholine receptor subunit alpha-10
基因别名: CHRNA10; NACHRA10
UniProt ID: (Human) Q9GZZ6
Entrez Gene ID: (Human) 57053, (Mouse) 504186
分子生物学功能:
ligand-gated ion channel
signal transduction
positive regulation of cytosolic calcium ion concentration
synaptic transmission, cholinergic
regulation of cell proliferation
inner ear morphogenesis
detection of mechanical stimulus involved in sensory perception of sound
calcium ion transmembrane transport
cation transmembrane transport
