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Immunogen sequence: AEGRLALKLF RDLFANYTSA LRPVADTDQT LNVTLEVTLS QIIDMDERNQ VLTLYLWIRQ EWTDAYLRWD PNAYGGLDAI RIPSSLVWRP DIVLYNKADA QPPGSASTNV VLRHDGAVRW DAPAITRSSC RVDVAAFPFD AQHCGLTFGS WTHGGHQLDV RPRGAAASLA DFVENVEWRV LGMPARRRVL TYGCCSEPYP DVTFTLLLRR RAAAYV; Positive Samples: HL-60, U2OS; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: acetylcholine receptor; acetylcholine receptor, nicotinic, alpha 10 (neuronal); cholinergic receptor; cholinergic receptor, nicotinic alpha 10; cholinergic receptor, nicotinic, alpha 10 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 10; NACHR alpha-10; Neuronal acetylcholine receptor subunit alpha-10; Nicotinic acetylcholine receptor subunit alpha-10
基因别名: CHRNA10; NACHRA10
UniProt ID: (Human) Q9GZZ6
Entrez Gene ID: (Human) 57053
分子生物学功能:
ligand-gated ion channel
