Immunogen sequence: MHNAEYDVLH APPADDRDQS SMEDGEDTPV TKLQR
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 80%.
DENND5A (DENN domain-containing protein 5A) is a guanine nucleotide exchange factor (GEF) which activates RAB6A and RAB39A/RAB39B. It promotes the exchange of GDP to GTP by converting inactive GDP-bound Rab proteins to their active GTP form. DENND5A is also involved in the negative regulation of neurtie outgrowth. Mutations affecting this gene can result in epileptic encephalopathy, early infantile, 49 (EIEE49).
蛋白别名: DENN domain-containing protein 5A; DENN/MADD domain containing 5A; RAB6 interacting protein 1; Rab6-interacting protein 1; Rab6IP1
基因别名: DENND5A; KIAA1091; RAB6IP1
UniProt ID: (Human) Q6IQ26
Entrez Gene ID: (Human) 23258