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Invitrogen
DENND5A Recombinant Rabbit Monoclonal Antibody (14H6L8)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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DENND5A Antibody (702789) in WB
Western blot analysis was performed on Membrane enriched extracts (30µg lysate) of IMR-32 (Lane 1), SH-SY5Y (Lane 2), SK-N-AS (Lane 3), PC12 (Lane 4) and tissue extracts of Mouse Brain (Lane 5) and Rat Brain (Lane6). The blots were probed with Anti-DENND5A Recombinant Rabbit Monoclonal Antibody (Product # 702789, 1:5,000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 1:4,000 dilution). A 160 kDa band corresponding to DENND5A was observed... View More
产品信息
702789
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
14H6L8
抗原
Peptide corresponding to human DENND5A [aa828-aa847]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2734803
产品详细信息
This antibody is predicted to react with Monkey, Mouse, Rat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
DENND5A (DENN domain-containing protein 5A) is a guanine nucleotide exchange factor (GEF) which activates RAB6A and RAB39A/RAB39B. It promotes the exchange of GDP to GTP by converting inactive GDP-bound Rab proteins to their active GTP form. DENND5A is also involved in the negative regulation of neurtie outgrowth. Mutations affecting this gene can result in epileptic encephalopathy, early infantile, 49 (EIEE49).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DENN domain-containing protein 5A; DENN/MADD domain containing 5A; RAB6 interacting protein 1; Rab6-interacting protein 1; Rab6IP1
基因别名: 1500012B19Rik; AJ245569; AW496491; DENND5A; KIAA1091; mKIAA1091; ORF37; RAB6IP1
UniProt ID: (Human) Q6IQ26, (Mouse) Q6PAL8, (Rat) G3V7Q0
Entrez Gene ID: (Human) 23258, (Mouse) 19347, (Rat) 308942
