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Invitrogen
DNER Polyclonal Antibody
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产品信息
PA5-120373
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 140-240 of human DNER (NP_620711.3).
偶联物
形式
Liquid
浓度
0.56 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: Hela, HT-29, Mouse brain, Mouse eye, Mouse small intestine, Rat brain. The target is usually found in the following locations: Cell membrane, Single-pass type I membrane protein.
Immunogen sequence: PATGWTESMA PRQLQPVPAT QEPDKILPRS QATVTLPTWQ PKTGQKVVEM KWDQVEVIPD IACGNASSNS SAGGRLVSFE VPQNTSVKIR QDATASLILL W
靶标信息
DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Brain EGF repeat-containing transmembrane protein; Delta and Notch-like epidermal growth factor-related receptor; delta-notch-like EGF repeat-containing transmembrane; delta/notch-like EGF repeat containing; delta/notch-like EGF-related receptor; H_NH0150O02.1; transmembrane protein Bet; WUGSC:H_NH0150O02.1
基因别名: A930026D19Rik; BET; Bret; DNER; UNQ26; UNQ262/PRO299
UniProt ID: (Human) Q8NFT8, (Mouse) Q8JZM4
Entrez Gene ID: (Human) 92737, (Rat) 316573, (Mouse) 227325
