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Invitrogen
DOCK8 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-140262
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.4 mg/mL
规格
40 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: INRYSSAEIR KQFTLPPNLG QYHRQSISTS GFPSLQLPQF YDPVEPVDFE GLLMTHLNSL DVQLAQELGD FTDDDLDVVF
Highest antigen sequence indentity to the following orthologs: Mouse - 88%, Rat - 86%.
靶标信息
The Dedicator of cytokinesis protein 8 (DOCK8) is a member of the DOCK180 family of guanine nucleotide exchange factors. DOCK8 plays an essential role in humoral immune responses and is important in the proper formation of the B cell immunological synapse. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 1200017A24Rik; epididymis luminal protein 205; unnamed protein product
基因别名: HEL-205; HIES2; MRD2; ZIR8
UniProt ID: (Human) Q8NF50
Entrez Gene ID: (Human) 81704
small GTPase mediated signal transduction
regulation of Rho protein signal transduction
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
memory T cell proliferation
positive regulation of establishment of T cell polarity
cellular response to chemokine
positive regulation of T cell migration
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