Immunogen sequence: DNLTQVINLY KQLVRGEEVN GDATAGSIPG STSALLDLSG LDLPPAGTTY PAMPTRP
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 91%.
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
蛋白别名: ADP-ribosylation factor binding protein 1; ADP-ribosylation factor-binding protein GGA1; gamma-adaptin related protein 1; Gamma-adaptin-related protein 1; golgi-associated, gamma adaptin ear containing, ARF binding protein 1; Golgi-localized, gamma ear-containing, ARF-binding protein 1
UniProt ID: (Human) Q9UJY5
Entrez Gene ID: (Human) 26088