Proteintech

HIC1 Polyclonal Antibody

Name: HIC1 Polyclonal Antibody
Brand: Proteintech
SKU: 24949-1-AP

3 篇参考文献

查看其他11个HIC1抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (6)

HIC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 6

HIC1 Antibody (24949-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human testis tissue slide using 24949-1-AP ( HIC1 Antibody) at dilution of 1:50 (under 40x lens).

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Immunogen image

Immunogen Image HIC1 Polyclonal Antibody

产品信息

24949-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看2篇已发表文章 2篇已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

HIC1 Fusion Protein Ag21849 (89-408 aa encoded by BC157027)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.42 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: DGAEAAAAA AVAPGAEPSL GAVLAAASYL QIPDLVALCK KRLKRHGKYC HLRGGGGGGG GYAPYGRPGR GLRAATPVIQ ACYPSPVGPP PPPAAEPPSG PEAAVNTHCA ELYASGPGPA AALCASERRC SPLCGLDLSK KSPPGSAAPE RPLAERELPP RPDSPPSAGP AAYKEPPLAL PSLPPLPFQK LEEAAPPSDP FRGGSGSPGP EPPGRPDGPS LLYRWMKHEP GLGSYGDELG RERGSPSERC EERGGDAAVS PGGPPLGLAP PPRYPGSLDG PGAGGDGDDY KSSSEETGSS EDPSPPGGHL EGYPCPHLAY G (89-408 aa encoded by BC157027)

靶标信息

Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing. These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression. HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. Conversely, HIC-1 does not interact with components of the HDAC complex, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain.

仅用于科研。不用于诊断过程。未经明确授权不得转售。