Immunogen sequence: LGSGFKAERL RVNLRLVINR LKLLEKKKTE LAQKARKEIA DYLAAGKDER ARIRVEHIIR EDYLVEAMEI LELYCDLL
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.
蛋白别名: hIST1; increased sodium tolerance 1 homolog; IST1 homolog; IST1, endosomal sorting complex required for transport-III component; MGC117220; overexpressed in lung cancer 1; pm28; Putative MAPK-activating protein PM28
基因别名: IST1; KIAA0174; OLC1
UniProt ID: (Human) P53990
Entrez Gene ID: (Human) 9798