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Invitrogen
JHDM1D Polyclonal Antibody
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JHDM1D Antibody (PA5-96987) in WB
Western Blot analysis of JHDM1D in extracts of various cell lines using JHDM1D Polyclonal Antibody (Product # PA5-96987) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
产品信息
PA5-96987
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 417-735 of mouse KDM7A.
偶联物
形式
Liquid
浓度
4.33 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: LKEDGFQPQS YLVQGVKALH TALKLWMKKE LVSEHAFEIP DNVRPGHLIK ELSKVIRAIE EENGKPVKSQ GIPSVCPVSR PSNEASPPYH SRRKMRKLRD HNVRTPSNLD ILELHTREVL KRLEMCPWEE DLLSSKLNGK FNKHLQPSST VPEWRAKDND LRLLLTNGRI IKDERQLFAD RSLYTADSEN EEDKKPTQNA NMKTEQSSGR EEAESQGSPK PLNRIFTSVR SELRSRPSEY SDGSDSEDSG PDCTALKINF ATEDSESSGD EKKHEITSHF KEESDIVRNL LQKSQKPSRQ EIPVKRECPT STSTEEEAI; Positive Samples: HeLa, 293T, BT-474, Mouse brain, Mouse thymus, Mouse spleen, Rat brain, Rat thymus; Cellular Location: Nucleus
靶标信息
JHDM1D histone demethylase that specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. This specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. This demethylates H3K9me2 in absence of H3K4me3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
