Bioss

JNK1 + 3 Polyclonal Antibody

查看其他2个JNK1/JNK3抗体

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

BS-0501R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:100
-

免疫组化（石蜡） (IHC (P))

1:500
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

流式细胞分析 (Flow)

1:20-1:100
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Dog, Chicken, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human JNK1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: c-Jun N-terminal kinase 1; c-Jun N-terminal kinase 3; JNK-46; JNK1 beta1 protein kinase; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; JUN N-terminal kinase; MAP kinase 10; MAP kinase 8; MAP kinase p49 3F12; MAPK 10; MAPK 8; mitogen activated protein kinase 10; mitogen activated protein kinase 8; Mitogen-activated protein kinase 10; Mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; p54 gamma; p54-beta; protein kinase mitogen-activated 8; SAPK gamma; SAPK-beta; SAPK/Erk/kinase 2; SAPK1b; SAPK1c; Stress activated protein kinase beta; stress-activated protein kinase 1; Stress-activated protein kinase 1b; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1; Stress-activated protein kinase JNK3

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基因别名: AI849689; C230008H04Rik; JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; JNK3; JNK3A; JNK3B1; JNK3B2; MAPK10; MAPK8; p493F12; p54bSAPK; PRKM10; PRKM8; SAPb; SAPK(beta); SAPK1; SAPK1B; SAPK1C; SAPKC; Serk2

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UniProt ID: (Human) P53779, (Human) P45983, (Mouse) Q61831, (Rat) P49187, (Rat) P49185, (Mouse) Q91Y86

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Entrez Gene ID: (Human) 5602, (Dog) 478464, (Chicken) 422592, (Human) 5599, (Chicken) 423778, (Dog) 477746, (Mouse) 26414, (Rat) 25272, (Rat) 116554, (Mouse) 26419

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功能
JUN kinase activity MAP kinase kinase activity protein binding ATP binding protein serine/threonine kinase activity kinase activity enzyme binding histone deacetylase regulator activity histone deacetylase binding nucleotide binding protein kinase activity MAP kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
参与通路
activation of MAPK activity protein phosphorylation signal transduction JNK cascade JUN phosphorylation response to light stimulus Fc-epsilon receptor signaling pathway regulation of circadian rhythm rhythmic process regulation of sequence-specific DNA binding transcription factor activity response to stress response to UV positive regulation of gene expression regulation of macroautophagy peptidyl-serine phosphorylation peptidyl-threonine phosphorylation regulation of histone deacetylation positive regulation of cyclase activity negative regulation of protein binding regulation of protein localization positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of protein metabolic process cellular response to lipopolysaccharide cellular response to mechanical stimulus positive regulation of deacetylase activity positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway negative regulation of transcription from RNA polymerase II promoter phosphorylation locomotor rhythm MAPK cascade ossification regulation of transcription, DNA-templated inflammatory response response to osmotic stress response to heat regulation of gene expression positive regulation of cell migration positive regulation of microtubule polymerization neuron projection development response to hydrogen peroxide positive regulation of DNA replication response to cadmium ion determination of dorsal identity cellular response to hydrogen peroxide cellular response to nitric oxide type B pancreatic cell apoptotic process neuronal stem cell population maintenance programmed necrotic cell death positive regulation of determination of dorsal identity positive regulation of apoptotic signaling pathway
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