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Invitrogen
JNK1/JNK3 Recombinant Rabbit Monoclonal Antibody (JJ08-86)
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产品信息
MA5-32453
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JJ08-86
抗原
Recombinant protein within Human JNK1 + JNK3 aa 1-423
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-Jun N-terminal kinase 1; c-Jun N-terminal kinase 3; JNK-46; JNK1 beta1 protein kinase; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; JUN N-terminal kinase; MAP kinase 10; MAP kinase 8; MAP kinase p49 3F12; MAPK 10; MAPK 8; mitogen activated protein kinase 10; mitogen activated protein kinase 8; Mitogen-activated protein kinase 10; Mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; p54 gamma; p54-beta; protein kinase mitogen-activated 8; SAPK gamma; SAPK-beta; SAPK/Erk/kinase 2; SAPK1b; SAPK1c; Stress activated protein kinase beta; stress-activated protein kinase 1; Stress-activated protein kinase 1b; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1; Stress-activated protein kinase JNK3
基因别名: AI849689; C230008H04Rik; JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; JNK3; JNK3A; JNK3B1; JNK3B2; MAPK10; MAPK8; p493F12; p54bSAPK; PRKM10; PRKM8; SAPb; SAPK(beta); SAPK1; SAPK1B; SAPK1C; SAPKC; Serk2
UniProt ID: (Human) P53779, (Human) P45983, (Mouse) Q61831, (Rat) P49187, (Rat) P49185, (Mouse) Q91Y86
Entrez Gene ID: (Human) 5602, (Human) 5599, (Mouse) 26414, (Rat) 25272, (Rat) 116554, (Mouse) 26419
JUN kinase activity
MAP kinase kinase activity
protein binding
ATP binding
protein serine/threonine kinase activity
kinase activity
enzyme binding
histone deacetylase regulator activity
histone deacetylase binding
nucleotide binding
protein kinase activity
MAP kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
activation of MAPK activity
protein phosphorylation
signal transduction
JNK cascade
JUN phosphorylation
response to light stimulus
Fc-epsilon receptor signaling pathway
regulation of circadian rhythm
rhythmic process
regulation of sequence-specific DNA binding transcription factor activity
response to stress
response to UV
positive regulation of gene expression
regulation of macroautophagy
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
regulation of histone deacetylation
positive regulation of cyclase activity
negative regulation of protein binding
regulation of protein localization
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of protein metabolic process
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
positive regulation of deacetylase activity
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
negative regulation of transcription from RNA polymerase II promoter
phosphorylation
locomotor rhythm
MAPK cascade
ossification
regulation of transcription, DNA-templated
inflammatory response
response to osmotic stress
response to heat
regulation of gene expression
positive regulation of cell migration
positive regulation of microtubule polymerization
neuron projection development
response to hydrogen peroxide
positive regulation of DNA replication
response to cadmium ion
determination of dorsal identity
cellular response to hydrogen peroxide
cellular response to nitric oxide
type B pancreatic cell apoptotic process
neuronal stem cell population maintenance
programmed necrotic cell death
positive regulation of determination of dorsal identity
positive regulation of apoptotic signaling pathway
