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Proteintech
KLF17 Polyclonal Antibody
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产品信息
17612-1-AP
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLF17 Fusion Protein Ag11776 (1-389 aa encoded by BC049844)
偶联物
形式
Liquid
浓度
0.4 mg/mL
规格
60 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MYGRPQAEM EQEAGELSRW QAAHQAAQDN ENSAPILNMS SSSGSSGVHT SWNQGLPTIQ HFPHSAEMLG SPLVSVEAPG QNVNEGGPQF SMPLPERGMS YCPQATLTPS RMIYCQRMSP PQQEMTIFSG PQLMPVGEPN IPRVARPFGG NLRMPPSGLP VSASTGIPIM SHTGNPPVPY PGLSTVPSDE TLLGPTVPST EAQAVLPSMA QMLPPQDAHD LGMPPAESQS LLVLGSQDSL VSQPDSQEGP FLPEQPGPAP QTVEKNSRPQ EGTGRRGSSE ARPYCCNYEN CGKAYTKRSH LVSHQRKHTG ERPYSCNWES CSWSFFRSDE LRRHMRVHTR YRPYKCDQCS REFMRSDHLK QHQKTHRPGP SDPQANNNNG EQDSPPAAGP (1-389 aa encoded by BC049844)
靶标信息
KLF17 is a transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ40160; Krueppel-like factor 17; Kruppel like factor 17; novel zinc-finger protein; unnamed protein product; Zinc finger protein 393; ZLF393
基因别名: KLF17; Zfp393; ZLF393; ZNF393
UniProt ID: (Human) Q5JT82
Entrez Gene ID: (Human) 128209
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
metal ion binding
sequence-specific double-stranded DNA binding
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