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产品信息
PA5-50340
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化（石蜡） (IHC (P)) |
1:25-1:100 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Fusion protein corresponding to residues near the C terminal of human Kruppel-like factor 17 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1.3 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2635793 |
产品详细信息
The antibody detects endogenous levels of total KLF17 protein.
靶标信息
KLF17 is a transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ40160; Krueppel-like factor 17; Kruppel-like factor 17; novel zinc-finger protein; Zinc finger protein 393; ZLF393
基因别名: KLF17; Zfp393; ZNF393
UniProt ID: (Human) Q5JT82
Entrez Gene ID: (Human) 128209
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription regulatory region DNA binding
metal ion binding
