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Invitrogen
KLF17 Polyclonal Antibody
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KLF17 Antibody (PA5-89403) in WB
Western blot analysis of KLF17 in extracts of various cell lines. Samples were incubated with KLF17 Polyclonal antibody (Product # PA5-89403) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-89403
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 210-389 of human KLF17 (NP_7757553)
偶联物
形式
Liquid
浓度
0.53 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: QMLPPQDAHD LGMPPAESQS LLVLGSQDSL VSQPDSQEGP FLPEQPGPAP QTVEKNSRPQ EGTGRRGSSE ARPYCCNYEN CGKAYTKRSH LVSHQRKHTG ERPYSCNWES CSWSFFRSDE LRRHMRVHTR YRPYKCDQCS REFMRSDHLK QHQKTHRPGP SDPQANNNNG EQDSPPAAGP; Positive Samples: U-87MG, HepG2, MCF7, Mouse brain; Cellular Location: Nucleus
靶标信息
KLF17 is a transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ40160; germ cell specific zinc finger protein; Germ cell-specific zinc finger protein; Krueppel-like factor 17; Kruppel-like factor 17; novel zinc-finger protein; Zinc finger protein 393; ZLF393
基因别名: 7420700M05Rik; AA420409; AU043468; C85123; D4Ertd561e; Gzf; KLF17; Zfp393; ZNF393
UniProt ID: (Human) Q5JT82, (Mouse) Q8CFA7
Entrez Gene ID: (Human) 128209, (Mouse) 75753
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription regulatory region DNA binding
metal ion binding
nucleic acid binding
DNA binding
C2H2 zinc finger transcription factor
