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Invitrogen
LAIR1 Monoclonal Antibody (NKTA255), APC
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LAIR1 Antibody (MA562283) in Flow
Flow cytometry (surface staining) of LAIR1 in human peripheral whole blood. Samples were stained with LAIR1 monoclonal antibody (Product # MA562283) using a dilution of 10 µL reagent/100 µL of peripheral whole blood. Separation of human CD305 positive CD19 positive B cells (red-filled) from neutrophil granulocytes (black-dashed).
产品信息
MA562283
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
NKTA255
抗原
Activated NK cells and CD3- thymocytes.
偶联物
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CD305, also known as LAIR1, is a type I transmembrane glycoprotein with an extracellular Ig-like domain and two intracellular ITIMs. It is expressed on a wide range of immune cells, including T, NK, and B cells, monocytes, dendritic cells, eosinophils, basophils, and mast cells. In humans, CD305 is also present on CD34+ hematopoietic progenitor cells and thymocytes. Several isoforms exist due to alternative splicing, with expression varying between cell types. CD305 functions as an inhibitory receptor, playing a key role in regulating immune responses. It blocks cytokine-mediated signaling, cell proliferation, and apoptosis. In NK, B, and T cells, CD305 modulates cytolytic functions and cytokine production, down-regulating IL2 and IFNG in CD4+ T cells while inducing transforming growth factor beta. In B cells, it reduces IgG and IgE production and decreases IL8, IL10, and TNF secretion. Activation of CD305 through tyrosine phosphorylation recruits phosphatases PTPN6 and PTPN11, although it may also function independently of SH2-containing phosphatases. It inhibits differentiation of peripheral blood precursors into dendritic cells and has been shown to induce apoptosis in myeloid leukemia cell lines. Collagens are identified as ligands for CD305, underscoring its role in immune regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD305; immunoglobulin heavy chain variable region; LAIR-1; leukocyte-associated Ig-like receptor 1; Leukocyte-associated immunoglobulin-like receptor 1
基因别名: CD305; LAIR-1; LAIR1
UniProt ID: (Human) Q6GTX8
Entrez Gene ID: (Human) 3903
