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Proteintech
MARK2 Polyclonal Antibody
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产品信息
15492-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MARK2 Fusion Protein Ag7884 (10-372 aa encoded by BC008771)
偶联物
形式
Liquid
浓度
0.23 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: LNERDTEQP TLGHLDSKPS SKSNMIRGRN SATSADEQPH IGNYRLLKTI GKGNFAKVKL ARHILTGKEV AVKIIDKTQL NSSSLQKLFR EVRIMKVLNH PNIVKLFEVI ETEKTLYLVM EYASGGEVFD YLVAHGRMKE KEARAKFRQI VSAVQYCHQK FIVHRDLKAE NLLLDADMNI KIADFGFSNE FTFGNKLDTF CGSPPYAAPE LFQGKKYDGP EVDVWSLGVI LYTLVSGSLP FDGQNLKELR ERVLRGKYRI PFYMSTDCEN LLKKFLILNP SKRGTLEQIM KDRWMNVGHE DDELKPYVEP LPDYKDPRRT ELMVSMGYTR EEIQDSLVGQ RYNEVMATYL LLGYKSSELE GDTI (10-372 aa encoded by BC008771)
靶标信息
MARK2 is a serine/threonine protein kinase involved in the control of cell polarity and microtubule stability. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ELKL motif kinase; ELKL motif kinase 1; EMK-1; EMK1; MAP/microtubule affinity-regulating kinase 2; MARK2; mark2 {ECO:0000312|RGD:708483}; MGC99619; OTTHUMP00000218338; OTTHUMP00000218339; OTTHUMP00000218340; OTTHUMP00000218343; Par-1b; PAR1 homolog; PAR1 homolog b; Ser/Thr protein kinase PAR-1B; serine/threonine kinase; serine/threonine protein kinase EMK; Serine/threonine-protein kinase MARK2; testicular tissue protein Li 117
基因别名: Emk; EMK-1; EMK1; MARK2; PAR-1; Par-1b; Par1b
UniProt ID: (Human) Q7KZI7, (Rat) O08679, (Mouse) Q05512
Entrez Gene ID: (Human) 2011, (Rat) 60328, (Mouse) 13728
magnesium ion binding
protein serine/threonine kinase activity
protein binding
ATP binding
lipid binding
protein kinase activator activity
poly(A) RNA binding
tau-protein kinase activity
cadherin binding involved in cell-cell adhesion
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
microtubule cytoskeleton organization
mitophagy
neuron migration
protein phosphorylation
positive regulation of neuron projection development
Wnt signaling pathway
peptidyl-threonine phosphorylation
establishment of cell polarity
activation of protein kinase activity
intracellular signal transduction
establishment or maintenance of epithelial cell apical/basal polarity
protein autophosphorylation
regulation of axonogenesis
regulation of cytoskeleton organization
mitochondrion localization
cell-cell adhesion
multicellular organism development
phosphorylation
cell differentiation
