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Proteintech
MSL1 Polyclonal Antibody
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产品信息
24373-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MSL1 Fusion Protein Ag18024 (264-614 aa encoded by BC122543)
偶联物
形式
Liquid
浓度
0.32 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MERRMQLVK KDNEKERHKL FQGYETEERE ETELSEKIKL ECQPELSETS QTLPPKPFSC GRSGKGHKRK SPFGSTERKT PVKKLAPEFS KVKTKTPKHS PIKEEPCGSL SETVCKRELR SQETPEKPRS SVDTPPRLST PQKGPSTHPK EKAFSSEIED LPYLSTTEMY LCRWHQPPPS PLPLRESSPK KEETVARCLM PSSVAGETSV LAVPSWRDHS VEPLRDPNPS DLLENLDDSV FSKRHAKLEL DEKRRKRWDI QRIREQRILQ RLQLRMYKKK GIQESEPEVT SFFPEPDDVE SLMITPFLPV VAFGRPLPKL TPQNFELPWL DERSRCRLEI QKKQTPHRTC RK (264-614 aa encoded by BC122543)
靶标信息
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Male-specific lethal 1 homolog; Male-specific lethal 1-like 1; Male-specific lethal-1 homolog 1; MSL-1; MSL1-like 1
基因别名: hMSL1; MSL-1; MSL1; MSL1L1
UniProt ID: (Human) Q68DK7
Entrez Gene ID: (Human) 339287
