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Proteintech
NELFE Polyclonal Antibody
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产品信息
10705-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NELFE Fusion Protein Ag1186 (1-333 aa encoded by BC011600)
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
10705-1-AP is obtained by immunizing animals with full-length RDBP of human origin.
Immunogen sequence: MLVIPPGLS EEEEALQKKF NKLKKKKKAL LALKKQSSSS TTSQGGVKRS LSEQPVMDTA TATEQAKQLV KSGAISAIKA ETKNSGFKRS RTLEGKLKDP EKGPVPTFQP FQRSISADDD LQESSRRPQR KSLYESDRLR ELGPDGEEAE GPGAGDGPPR SFDWGYEERS GAHSSASPPR SRSRDRSHER NRDRDREGPF RRSDSFPERR APRKGNTLYV YGEDMTPTLL RGAFSPFGNI IDLSMDPPRN CAFVTYEKME SADQAVAELN GTQVESVQLK VNIARKQPML DAATGKSVWG SLAVQNSPKG CHRDKRTQIV YSDDVYKENL VDGF (1-333 aa encoded by BC011600)
靶标信息
RDBP is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: major histocompatibility complex gene RD; Negative elongation factor E; negative elongation factor polypeptide E; NELF E; NELF-E; nuclear protein; RD RNA binding protein; RD RNA-binding protein; RNA-binding protein RD
基因别名: D17H6S45; D6S45; NELF-E; NELFE; RD; RDBP; RDP
UniProt ID: (Human) P18615, (Mouse) P19426
Entrez Gene ID: (Human) 7936, (Mouse) 27632, (Rat) 294258
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
biological_process
negative regulation of transcription elongation from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
positive regulation of viral transcription
positive regulation of histone H3-K4 methylation
positive regulation of ERK1 and ERK2 cascade
negative regulation of mRNA polyadenylation
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
