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OriGene
NR4A3 Monoclonal Antibody (OTI4D1), TrueMAB™
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NR4A3 Antibody (CF804895) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NR4A3 (RC218250, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-NR4A3. Positive lysates LY429326 (100 µg) and LC429326 (20 µg) can be purchased separately from OriGene.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
CF804895
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI4D1
抗原
Human recombinant protein fragment corresponding to amino acids 332-626 of human NR4A3 produced in E.coli.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
NOR-1, a NR4 nerve growth factor-like receptor, has been shown to affect neuronal development, T-cell apoptosis, and cancer development. NOR-1 binds to NBRE (NGFI-B response element) and regulates the pro-opiomelanocortin (POMC) gene. NOR-1 is induced rapidly but transiently by a variety of stimuli. Downregulation of NOR-1 and other NGFI-B family members is correlated with drug addiction-prone behavior of Lewis rats. Three human protein isoforms have been documented: NOR-1, NOR-1beta, and NOR-1 3' variant.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: chondrosarcoma, extraskeletal myxoid, fused to EWS; mitogen-induced nuclear orphan receptor; neuron-derived orphan receptor 1; nuclear hormone receptor NOR-1; steroid/thyroid orphan receptor homolog gene; TEC receptor; translocated in extraskeletal chondrosarcoma
基因别名: CHN; CSMF; MINOR; NOR1
UniProt ID: (Human) Q92570
Entrez Gene ID: (Human) 8013
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
protein kinase binding
histone acetyltransferase binding
glucocorticoid receptor binding
cAMP response element binding
protein homodimerization activity
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
gastrulation
positive regulation of cardiac muscle hypertrophy
positive regulation of glucose transport
intracellular steroid hormone receptor signaling pathway
intracellular receptor signaling pathway
positive regulation of mast cell cytokine production
intracellular signal transduction
common myeloid progenitor cell proliferation
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
mast cell degranulation
cellular response to leptin stimulus
cellular respiration
fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
platelet-derived growth factor receptor signaling pathway
regulation of smooth muscle cell proliferation
positive regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
negative regulation of inflammatory response
regulation of type B pancreatic cell proliferation
cellular response to corticotropin-releasing hormone stimulus
cellular response to catecholamine stimulus
energy homeostasis
positive regulation of monocyte aggregation
positive regulation of vascular smooth muscle cell proliferation
positive regulation of vascular associated smooth muscle cell migration
positive regulation of feeding behavior
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