Proteintech

PERK/EIF2AK3 Polyclonal Antibody

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PERK/EIF2AK3 Polyclonal Antibody

产品信息

24390-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200-1:1,000
查看63篇已发表文章 63篇已发表文章

免疫组化 (IHC)

-
查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200
-

免疫细胞化学 (ICC/IF)

1:20-1:200
查看1篇已发表文章 1篇已发表文章

不适用 (N/A)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human

已发表种属

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

PERK/EIF2AK3 Fusion Protein Ag18254 (767-1116 aa encoded by BC126354)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.33 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: TDCDVEDGT MDGNDEGHSF ELCPSEASPY VRSRERTSSS IVFEDSGCDN ASSKEEPKTN RLHIGNHCAN KLTAFKPTSS KSSSEATLSI SPPRPTTLSL DLTKNTTEKL QPSSPKVYLY IQMQLCRKEN LKDWMNGRCT IEERERSVCL HIFLQIAEAV EFLHSKGLMH RDLKPSNIFF TMDDVVKVGD FGLVTAMDQD EEEQTVLTPM PAYARHTGQV GTKLYMSPEQ IHGNSYSHKV DIFSLGLILF ELLYPFSTQM ERVRTLTDVR NLKFPPLFTQ KYPCEYVMVQ DMLSPSPMER PEAINIIENA VFEDLDFPGK TVLRQRSRSL SSSGTKHSRQ SNNSHSPLPS N (767-1116 aa encoded by BC126354)

靶标信息

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PRKR-like endoplasmic reticulum kinase; Protein tyrosine kinase EIF2AK3

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基因别名: EIF2AK3; PEK; PERK; WRS

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UniProt ID: (Human) Q9NZJ5

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Entrez Gene ID: (Human) 9451

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功能
protein kinase activity protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity protein binding ATP binding enzyme binding protein phosphatase binding identical protein binding protein homodimerization activity Hsp90 protein binding non-receptor serine/threonine protein kinase
参与通路
skeletal system development ossification angiogenesis chondrocyte development protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process ER overload response endoplasmic reticulum organization positive regulation of vascular endothelial growth factor production positive regulation of gene expression regulation of translational initiation by eIF2 alpha phosphorylation negative regulation of translation peptidyl-serine phosphorylation calcium-mediated signaling insulin secretion bone mineralization endoplasmic reticulum unfolded protein response endocrine pancreas development negative regulation of myelination negative regulation of translational initiation in response to stress cellular response to amino acid starvation response to endoplasmic reticulum stress eiF2alpha phosphorylation in response to endoplasmic reticulum stress PERK-mediated unfolded protein response cellular response to glucose starvation positive regulation of transcription from RNA polymerase I promoter protein autophosphorylation insulin-like growth factor receptor signaling pathway protein homooligomerization regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation cellular response to cold positive regulation of protein localization to nucleus regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway response to manganese-induced endoplasmic reticulum stress
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