Search Thermo Fisher Scientific
Immunogen sequence: VGHNMMMDLL HLHEKFFRPL PESYDQFKQN IHSLFPVLID TKSVTKDIWK EMNFPRVSNL SEVYEVLNSD LNPT
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: HsPNLDC1; PARN-like domain-containing protein 1; poly(A)-specific ribonuclease (PARN)-like domain containing 1; Poly(A)-specific ribonuclease domain-containing protein 1; Poly(A)-specific ribonuclease PNLDC1
基因别名: PNLDC1
UniProt ID: (Human) Q8NA58
Entrez Gene ID: (Human) 154197
分子生物学功能: mRNA polyadenylation factor