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Invitrogen
Perforin Monoclonal Antibody (dG9), FITC
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Perforin Antibody (MA562395) in Flow
Flow cytometry (intracellular staining) of Perforin in human lymphocytes. Samples were stained with Perforin monoclonal antibody (Product # MA562395) using a dilution of 10 µL reagent/100 µL of peripheral whole blood. Multicolor surface staining pattern of human lymphocytes using anti-human CD56 (LT56) APC antibody (10 µL reagent/100 µL of peripheral whole blood).
产品信息
MA562395
产品规格
种属反应
Bovine,
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
dG9
抗原
Purified granules from human YT lymphoma cell line.
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Perforin is one of the major cytolytic proteins of cytolytic granules. Perforin is a cytolytic mediator and is stored in and released by cytoplasmic granules. Moreover, perforin is involved in immune defense against tumors and virus infections as mediated by cytotoxic lymphocytes. Perforin is a 555 amino acid protein with a 21 amino acid signal peptide, and has a molecular weight of 70 to 75 kD. Perforin is a pore forming protein with a mechanism of transmembrane channel formation similar to C9, and homology between perforin and C9 have been demonstrated. Studies show that perforin is expressed only in killer cell lines and not in helper T lymphocytes or other tumor cells tested. Perforin is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants of perforin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
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生物信息学
蛋白别名: Cytolysin; lymphocyte pore forming protein; Lymphocyte pore-forming protein; OMAK; OTTHUMP00000019759; P1; perforin 1 (pore forming protein); Perforin-1; Perforin1; PFP; PGFL; PIGF; PIGF-2; PLGF; PRF1 (pore forming protein 1); RP11-710A11.3
基因别名: FLH2; HPLH2; P1; PFN1; PFP; PRF1
UniProt ID: (Human) P14222
Entrez Gene ID: (Human) 5551, (Bovine) 369025
