A suggested positive control for Western blot is K562 cells; suggested positive control for IHC is human breast carcinoma.
DOK1 (P62dok, Docking protein 1) is believed to be a mainly cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. DOK1 is a major substrate for many tyrosine kinases including c-kit, v-abl, vFPS, EGF, and PDGF. Upon phosphorylation by kinases, DOK1 forms a complex with ras GTPase-activating protein. Phosphorylation on tyrosine residues by the insulin receptor kinase results in the negative regulation of the insulin signaling pathway. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs.
蛋白别名: Docking protein 1; docking protein 1, 62kDa (downstream of tyrosine kinase 1); DOK 1; Downstream of tyrosine kinase 1; downstream of tyrosine kinase-1; MGC117395; MGC138860; p62 dok; p62(dok); pp62; TLP1; TP1; TROVE domain family; TROVE1; VAULT2
基因别名: AW557123; Dok; Dok-1; DOK1; P62DOK; pp62