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产品信息
PA5-64790
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:1,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthesized peptide derived from human EPHB1/2 (Phospho-Tyr778/Tyr780) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS, pH 7.4, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2662984 |
产品详细信息
Phospho-EphB1/EphB2 (Tyr778, Tyr780) Polyclonal Antibody detects endogenous levels of EphB1/EphB2 only when phosphorylated at Tyr778, Tyr780.
靶标信息
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase family. The protein encoded by this gene is a receptor for ephrin-B family members.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Developmentally-regulated Eph-related tyrosine kinase; EK5; EK6; ELK; ELK-related protein tyrosine kinase; ELK-related tyrosine kinase; Eph receptor B2 (ELK-related protein tyrosine kinase); EPH tyrosine kinase 2; EPH tyrosine kinase 3; EPH-like kinase 5; EPH-like kinase 6; EphB2/CTF1; EphB2/CTF2; EPHB3; Ephrin B1; Ephrin B2; Ephrin type-B receptor 1; Ephrin type-B receptor 2; EphrinB1; EphrinB2; ETK2; FLJ37986; HEK-6; HEK2; MGC87492; NET; Neural kinase; Neuronally-expressed EPH-related tyrosine kinase; Nuk receptor tyrosine kinase; protein-tyrosine kinase HEK5; Renal carcinoma antigen NY-REN-47; soluble EPHB1 variant 1; TYRO6; Tyrosine-protein kinase receptor EPH-2; Tyrosine-protein kinase receptor EPH-3; Tyrosine-protein kinase receptor SEK-3; Tyrosine-protein kinase TYRO5
基因别名: 9330129L11; AW488255; C130099E04Rik; CAPB; Cek5; Cek6; DRT; EK5; ELK; Elkh; ENSMUSG00000074119; EPHB1; EPHB2; EPHT2; EPHT3; Epth2; EPTH3; ERK; ETECK; HEK5; HEK6; NET; Nuk; PCBC; Prkm5; Qek5; RGD1564232; Sek3; TYRO5
UniProt ID: (Human) P54762, (Human) P29323, (Rat) P09759, (Mouse) Q8CBF3, (Mouse) P54763
Entrez Gene ID: (Human) 2047, (Human) 2048, (Rat) 24338, (Mouse) 270190, (Mouse) 13844, (Rat) 313633
分子生物学功能:
transmembrane signal receptor
angiogenesis
immunological synapse formation
axon guidance
peptidyl-tyrosine phosphorylation
optic nerve morphogenesis
central nervous system projection neuron axonogenesis
neurogenesis
establishment of cell polarity
retinal ganglion cell axon guidance
cell-substrate adhesion
regulation of JNK cascade
protein autophosphorylation
ephrin receptor signaling pathway
camera-type eye morphogenesis
detection of temperature stimulus involved in sensory perception of pain
positive regulation of synapse assembly
cell chemotaxis
dendritic spine development
dendritic spine morphogenesis
neural precursor cell proliferation
regulation of ERK1 and ERK2 cascade
regulation of neuron death
urogenital system development
nervous system development
axonal fasciculation
learning
phosphorylation
corpus callosum development
inner ear morphogenesis
positive regulation of long-term neuronal synaptic plasticity
negative regulation of axonogenesis
regulation of body fluid levels
palate development
commissural neuron axon guidance
cranial nerve development
protein phosphorylation
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
cell morphogenesis
multicellular organism development
organ morphogenesis
regulation of neuronal synaptic plasticity
regulation of axonogenesis
biological_process
transmembrane-ephrin receptor activity
protein binding
ATP binding
axon guidance receptor activity
protein complex binding
protein tyrosine kinase activity
receptor binding
identical protein binding
ephrin receptor activity
nucleotide binding
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
receptor activity
molecular_function
