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产品信息
PA5-17908
产品规格
种属反应
Hamster,
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to residues surrounding pSer256 of human Fox01
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10982175
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Translocated To, 7) and is a member of the O class of forkhead/ winged helix family of transcription factors along with FOXO1, FOXO3 and FOXO6. FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. FOXO4 binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. However, the activation of another downstream target of the Insulin/IGF1 pathway, Akt, leads to phosphorylation of FOXO4 on specific Ser/Thr residues. This phosphorylation mediates binding of FOXO4 to 14-3-3 and eventual exit of FOXO4 from the nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Afxh; AFXzeta; Fork head domain transcription factor AFX1; forkhead box O4; Forkhead box protein O4; forkhead protein; FOXO4b; MGC120490; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7; OTTHUMP00000023497
基因别名: AFX; AFX1; Afxh; Fkhr3; FOXO4; MLLT7
UniProt ID: (Human) Q3KPF1, (Mouse) Q9WVH3
Entrez Gene ID: (Human) 4303, (Chinese hamster) 100756577, (Mouse) 54601
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cell cycle
cell cycle arrest
mitotic G2 DNA damage checkpoint
multicellular organism development
muscle organ development
negative regulation of cell proliferation
insulin receptor signaling pathway
anatomical structure morphogenesis
negative regulation of angiogenesis
cell differentiation
positive regulation of transcription, DNA-templated
stem cell differentiation
negative regulation of smooth muscle cell differentiation
negative regulation of G0 to G1 transition
positive regulation of transcription from RNA polymerase II promoter
positive regulation of cell cycle arrest
