Invitrogen

Phospho-Syk (Tyr323, Tyr317) Polyclonal Antibody

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

1 Reference
View all (41) Syk antibodies
Datasheet
Protocols
Tech Support
Datasheet
Protocols
Tech Support

Product Details

44-234G

Applications
Tested Dilution
Publications

免疫印迹 (WB)

1:1,000
查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

1:250
-
产品规格

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

分类

Polyclonal

类型

Antibody

Immunogen

The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human Syk that contains tyrosine 323 (tyrosine 317 in the mouse sequence).
View immunogen

Conjugate

Unconjugated

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

Dulbecco's PBS, pH 7.3, with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20°C

RRID

AB_2533612

Target Information

Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Bioinformatics

Protein Aliases: DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72-Syk; SP1; Spleen tyrosine kinase; syk signaling; tyrosine-kinase syk; Tyrosine-protein kinase SYK

View more View less

Gene Aliases: p72-Syk; ptk72; SYK; Sykb

View more View less

UniProt ID: (Human) P43405, (Mouse) P48025

View more View less

Entrez Gene ID: (Human) 6850, (Mouse) 20963

View more View less

Molecular Function: kinase modulator

Function(s)
angiogenesis lymph vessel development positive regulation of receptor internalization stimulatory C-type lectin receptor signaling pathway adaptive immune response macrophage activation involved in immune response neutrophil activation involved in immune response leukocyte activation involved in immune response serotonin secretion by platelet protein phosphorylation inflammatory response leukocyte cell-cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway integrin-mediated signaling pathway activation of JUN kinase activity cell proliferation organ morphogenesis regulation of platelet activation regulation of tumor necrosis factor-mediated signaling pathway viral process peptidyl-serine phosphorylation leukotriene biosynthetic process platelet activation neutrophil chemotaxis receptor internalization positive regulation of type I interferon production regulation of superoxide anion generation positive regulation of cell adhesion mediated by integrin peptidyl-tyrosine autophosphorylation Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis defense response to bacterium transcription factor import into nucleus positive regulation of mast cell degranulation regulation of neutrophil degranulation beta selection innate immune response positive regulation of interleukin-3 biosynthetic process positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of bone resorption positive regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell proliferation blood vessel morphogenesis positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation regulation of phagocytosis positive regulation of calcium-mediated signaling B cell receptor signaling pathway regulation of sequence-specific DNA binding transcription factor activity regulation of ERK1 and ERK2 cascade cellular response to molecule of fungal origin cellular response to low-density lipoprotein particle stimulus regulation of arachidonic acid secretion regulation of platelet aggregation activation of MAPK activity serotonin secretion immune system process cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway G-protein coupled receptor signaling pathway phosphorylation cell migration peptidyl-tyrosine phosphorylation signal transduction by protein phosphorylation cell differentiation intracellular signal transduction protein autophosphorylation regulation of immune response
Process(es)
protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity integrin binding protein binding ATP binding protein kinase binding nucleotide binding receptor binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein domain specific binding
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support