Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
1:1,000 | 查看1篇已发表文章 1篇已发表文章 |
免疫细胞化学 (ICC/IF) |
1:250 | - |
产品规格 | |
---|---|
种属反应 |
Human, Mouse |
已发表种属 |
Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human Syk that contains tyrosine 323 (tyrosine 317 in the mouse sequence). |
偶联物 |
Unconjugated |
形式 |
Liquid |
纯化类型 |
Antigen affinity chromatography |
保存液 |
Dulbecco's PBS, pH 7.3, with 1mg/mL BSA |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2533612 |
Syk is a cytoplasmic protein tyrosine kinase that translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72-Syk; SP1; Spleen tyrosine kinase; syk signaling; tyrosine-kinase syk; Tyrosine-protein kinase SYK
基因别名: p72-Syk; ptk72; SYK; Sykb
UniProt ID: (Human) P43405, (Mouse) P48025
Entrez Gene ID: (Human) 6850, (Mouse) 20963
分子生物学功能:
kinase modulator