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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:3,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human ULK1 (phospho Ser758). The exact sequence is proprietary. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.3 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7, with 1% BSA, 20% glycerol |
内含物 |
0.025% Proclin 300 |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2736429 |
Positive Control: MCF7, MCF-7 (starvation for 16 hr, incubated in EBSS for 4 hr, and 200 nM Rapamycin treatment for 0.5 hr)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
ULK1, also known as ATG1, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK1 results in a severe defect in the autophagy pathway. ULK1 is highly conserved among eukaryotes, and are the Unc-51-like kinases, ULK1 and ULK2 in mammals. ULK1 is ubiquitously expressed and involved in autophagy in response to starvation. It is the target of the TOR kinase signaling pathway that regulates autophagy through the control of phosphorylation status of ATG13. ULK1 also plays a role early in neuronal differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: APG1; ATG 1; ATG1; ATG1 autophagy related 1 homolog; Autophagy-related protein 1 homolog; C. elegans; EC:2.7.11.1; FLJ38455; Serine/threonine-protein kinase ULK1; ULK 1; UNC 51; Unc-51-like kinase 1
基因别名: ATG1; ATG1A; hATG1; KIAA0722; ULK1; UNC51; Unc51.1
UniProt ID: (Human) O75385
Entrez Gene ID: (Human) 8408
