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RAGE Antibody (710339) in WB
Western blot analysis of RAGE in whole cell extracts from HepG2 (lane 1), Jurkat (lane2), and MDAMB-231 (lane3) cells using a RAGE Recombinant Rabbit Superclonal™ Antibody (Product # 710339) at a dilution of 2 µg/mL. Samples were detected using chemiluminescence (ECL). Results show a band at ~32kDa.
产品信息
710339
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
17HCLC
抗原
Recombinant protein corresponding to amino acids 23-342 of human sRAGE
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with mouse, rat, non-human primate and rabbit based on sequence homology.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
靶标信息
The Receptor for Advanced Glycation End-products (RAGE) is a gene located on human chromosome 6p21.3, encoding a transmembrane receptor belonging to the immunoglobulin superfamily. RAGE is expressed in various tissues, with significant levels in the lungs, and plays a crucial role in cellular signaling and inflammation. As a receptor, RAGE binds multiple ligands, including advanced glycation end-products (AGEs), amyloid-β peptide, high mobility group box 1 (HMGB1), and S100/calgranulin proteins, facilitating diverse pathological processes like inflammation, cancer progression, and neurodegeneration. The interaction between RAGE and its ligands triggers intracellular signaling pathways such as NF-?B activation, leading to inflammatory responses and oxidative stress. In the context of chronic diseases like diabetes, Alzheimer's, and cardiovascular diseases, RAGE is a critical mediator, linking metabolic disturbance to cellular dysfunction. Therapeutic targeting of RAGE signaling is under investigation, aiming to mitigate its contribution to inflammatory and degenerative diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Advanced glycosylation end product-specific receptor; RAGE isoform NtRAGE-delta; RAGE isoform sRAGE-delta; RAGE-4 ORF3; receptor for advanced glycation end-products variant 20; Receptor for advanced glycosylation end products; sRAGE
基因别名: AGER; RAGE; SCARJ1
UniProt ID: (Human) Q15109
Entrez Gene ID: (Human) 177
regulation of T cell mediated cytotoxicity
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
negative regulation of endothelial cell proliferation
inflammatory response
negative regulation of cell adhesion
cell surface receptor signaling pathway
JAK-STAT cascade
brain development
glycoprotein metabolic process
response to wounding
response to fructose
positive regulation of autophagy
negative regulation of endothelial cell migration
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
positive regulation of fibroblast migration
response to activity
positive regulation of smooth muscle cell migration
lung development
neuron projection development
negative regulation of interleukin-10 production
positive regulation of interleukin-12 production
negative regulation of collagen biosynthetic process
response to vitamin A
response to genistein
negative regulation of osteoblast proliferation
cellular response to drug
positive regulation of activated T cell proliferation
positive regulation of neuron apoptotic process
innate immune response
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
positive regulation of NF-kappaB transcription factor activity
response to methylglyoxal
calcium ion homeostasis
response to hyperoxia
positive regulation of phagocytosis, engulfment
transdifferentiation
cellular response to hydrogen peroxide
cellular response to glucose stimulus
cellular response to fatty acid
cellular response to organic cyclic compound
response to selenite ion
positive regulation of potassium ion transmembrane transporter activity
positive regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
regulation of CD4-positive, alpha-beta T cell activation
positive regulation of type B pancreatic cell apoptotic process
positive regulation of dendritic cell differentiation
