Invitrogen

RAGE Monoclonal Antibody (CL10587)

RAGE Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 6

RAGE Antibody (MA562939) in IHC (P)

Immunohistochemistry analysis of RAGE in paraffin-embedded human lung and prostate tissues using RAGE Monoclonal Antibody (Product # MA562939). Corresponding AGER RNA-seq data are presented for the same tissues.

Product Image Gallery

产品信息

MA562939

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:200-1:500

产品规格

种属反应

Human, Rat

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

CL10587

抗原

Recombinant protein corresponding to Human AGER

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

靶标信息

The Receptor for Advanced Glycation End-products (RAGE) is a gene located on human chromosome 6p21.3, encoding a transmembrane receptor belonging to the immunoglobulin superfamily. RAGE is expressed in various tissues, with significant levels in the lungs, and plays a crucial role in cellular signaling and inflammation. As a receptor, RAGE binds multiple ligands, including advanced glycation end-products (AGEs), amyloid-β peptide, high mobility group box 1 (HMGB1), and S100/calgranulin proteins, facilitating diverse pathological processes like inflammation, cancer progression, and neurodegeneration. The interaction between RAGE and its ligands triggers intracellular signaling pathways such as NF-?B activation, leading to inflammatory responses and oxidative stress. In the context of chronic diseases like diabetes, Alzheimer's, and cardiovascular diseases, RAGE is a critical mediator, linking metabolic disturbance to cellular dysfunction. Therapeutic targeting of RAGE signaling is under investigation, aiming to mitigate its contribution to inflammatory and degenerative diseases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: Advanced glycosylation end product-specific receptor; advanced glycosylation end product-specific receptor variant 2; advanced glycosylation end product-specific receptor variant 3; advanced glycosylation end product-specific receptor variant 4; advanced glycosylation end product-specific receptor variant 5; RAGE isoform NtRAGE-delta; RAGE isoform sRAGE-delta; RAGE-4 ORF3; receptor for advanced glycation end-products variant 20; Receptor for advanced glycosylation end products; sRAGE

查看更多收起

基因别名: AGER; RAGE; SCARJ1

查看更多收起

UniProt ID: (Human) Q15109

查看更多收起

Entrez Gene ID: (Human) 177, (Rat) 81722

查看更多收起

功能

receptor activity transmembrane signaling receptor activity protein binding identical protein binding S100 protein binding advanced glycation end-product receptor activity high mobility group box 1 binding cell adhesion molecule immunoglobulin superfamily cell adhesion molecule

参与通路