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MUbio
Rec.Pr.Thyrosin Phosphate (RPTP) Monoclonal Antibody (3D7)
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产品信息
MUB1811P
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Pig,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
3D7
抗原
Rec.Pr.Thyrosin Phosphate (RPTP)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Monoclonal antibodies 3G4 and 3D7 have been directed anti the extracellular domain of rPTPu.
The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
靶标信息
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC166994; protein tyrosine phosphatase mu; protein tyrosine phosphatase receptor-type M; protein tyrosine phosphatase, receptor type, M; protein tyrosine phosphatase, receptor type, mu polypeptide; protein tyrosine phosphatase, receptor-type, M; Protein-tyrosine phosphatase mu; PTP mu; Ptpmu; Receptor-type tyrosine-protein phosphatase mu
基因别名: hR-PTPu; PTPRL1; PTPRM; R-PTP-MU; RPTPM; RPTPU
UniProt ID: (Human) P28827
Entrez Gene ID: (Pig) 100624854, (Human) 5797, (Rat) 29616
negative regulation of endothelial cell proliferation
protein dephosphorylation
homophilic cell adhesion via plasma membrane adhesion molecules
signal transduction
negative regulation of endothelial cell migration
retina layer formation
negative regulation of angiogenesis
neuron projection development
retinal ganglion cell axon guidance
peptidyl-tyrosine dephosphorylation
response to drug
positive regulation of vasodilation
