Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
SIM2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 1
SIM2 Antibody (PA5-90219) in WB
Western blot analysis of SIM2 in various lysates. Samples were incubated with SIM2 Polyclonal antibody (Product # PA5-90219) using a dilution of 1:400, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-90219
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 342-525 of human SIM2 (NP_0050601?)
偶联物
形式
Liquid
浓度
1.22 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LSLEQVSTAK SQDSWRTALS TSQETRKLVK PKNTKMKTKL RTNPYPPQQY SSFQMDKLEC GQLGNWRASP PASAAAPPEL QPHSESSDLL YTPSYSLPFS YHYGHFPLDS HVFSSKKPML PAKFGQPQGS PCEVARFFLS TLPASGECQW HYANPLVPSS SSPAKNPPEP PANTARHSLV PSYE; Positive Samples: U-251MG, HepG2; Cellular Location: Nucleus
靶标信息
This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: bHLHe15; Class E basic helix-loop-helix protein 15; mSIM; SIM transcription factor; single-minded 2; Single-minded homolog 2; transcription factor SIM2
基因别名: BHLHE15; HMC13F06; HMC29C01; SIM; SIM2
UniProt ID: (Human) Q14190, (Mouse) Q61079
Entrez Gene ID: (Human) 6493, (Rat) 304071, (Mouse) 20465
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein heterodimerization activity
signal transducer activity
protein binding
protein dimerization activity
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
embryonic pattern specification
cell differentiation
lung development
signal transduction
negative regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
