FIGURE: 1 / 1
Immunogen sequence: MQAAALPEEI RWLLEDAEEF LAEGLRNENL SAVARDHRDH ILRGFQQIKA RYYWDFQPQG GDIGQDSSDD NHSGTLGLSL TSDAPFLSDY QDEGMEDIVK GAQELDNVIK QGYLEKKSKD HSFFGSEWQK RWCVVSRGLF YYYANEKSKQ PKGTFLIKGY GVRMAPHLRR DSKKESCFEL TSQDRRSYEF TATSPAEARD WVDQISFLLK DLSSLTIPYE EDEEEEEKEE TYDDIDGFDS PSCGSQCRPT ILPGSVGIKE PTEEKEEEDI YEVLPDEEHD LEEDESGTRR KGDYASYYQG LWDCHGDQPD ELSFQRGDLI RILSKEYNMY GWWVGELNSL VGIVPKEYLT TAFEVEER; Positive Samples: Mouse thymus, Rat thymus; Cellular Location: Cell membrane, Cytoplasm, Nucleus
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.
Protein Aliases: ortholog of human src family associated phosphoprotein 1 SCAP1; pp55; SKAP-55; SKAP55 adapter protein; SKAP55 adaptor protein; src family associated phosphoprotein 1; Src family-associated phosphoprotein 1; Src kinase-associated phosphoprotein 1; Src kinase-associated phosphoprotein of 55 kDa
Gene Aliases: 1700091G21Rik; Scap1; Skap-55; Skap1; Skap55
Molecular Function: scaffold/adaptor protein