Invitrogen

SOCS1 Polyclonal Antibody

SOCS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SOCS1 Antibody (38-5200) in IHC (P)

Immunohistochemistry analysis of SOCS-1 showing staining in the cytoplasm and nucleus of paraffin-embedded human stomach carcinoma (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at roo... View More

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产品信息

38-5200

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

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免疫组化（石蜡） (IHC (P))

1:20

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产品规格

种属反应

Human, Mouse

已发表种属

Human, Insect, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Raised against the C-term of human SOCS1.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2533372

靶标信息

The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

A mutual regulatory loop between miR-155 and SOCS1 influences renal inflammation and diabetic kidney disease.

Molecular therapy. Nucleic acids

Prieto I,Kavanagh M,Jimenez-Castilla L,Pardines M,Lazaro I,Herrero Del Real I,Flores-Muñoz M,Egido J,Lopez-Franco O,Gomez-Guerrero C

Published figure using SOCS1 polyclonal antibody (Product # 38-5200) in Western Blot

Tue Dec 12 00:00:00 UTC 2023

A mutual regulatory loop between miR-155 and SOCS1 influences renal inflammation and diabetic kidney disease.

Molecular therapy. Nucleic acids

Prieto I,Kavanagh M,Jimenez-Castilla L,Pardines M,Lazaro I,Herrero Del Real I,Flores-Muñoz M,Egido J,Lopez-Franco O,Gomez-Guerrero C

Published figure using SOCS1 polyclonal antibody (Product # 38-5200) in Western Blot

Tue Dec 12 00:00:00 UTC 2023

Implication of Toll/IL-1 receptor domain containing adapters in Porphyromonas gingivalis-induced inflammation.

Innate immunity

Bugueno IM,Benkirane-Jessel N,Huck O

Published figure using SOCS1 polyclonal antibody (Product # 38-5200) in Western Blot

Sat May 01 00:00:00 UTC 2021

N⁶-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.

Developmental cell

Du J,Liao W,Liu W,Deb DK,He L,Hsu PJ,Nguyen T,Zhang L,Bissonnette M,He C,Li YC

38-5200 was used in Western Blot to show that m6A methylation-mediated SOCS1 induction is required to maintain the negative feedback of macrophage activation in response to bacterial infection.

Mon Dec 21 00:00:00 UTC 2020

Silencing of suppressor of cytokine signaling 1 enhances the immunological effect of mucin 1-calreticulin-primed 4T1 cell-treated dendritic cells in breast cancer treatment.

Oncology letters

Qin S,Gao Z,Liu Y,Liu C,Wang J,Zou LL

Published figure using SOCS1 polyclonal antibody (Product # 38-5200) in Western Blot

Thu Feb 01 00:00:00 UTC 2018

Induction of miR-155 after Brain Injury Promotes Type 1 Interferon and has a Neuroprotective Effect.

Frontiers in molecular neuroscience

Harrison EB,Emanuel K,Lamberty BG,Morsey BM,Li M,Kelso ML,Yelamanchili SV,Fox HS

38-5200 was used in Western Blotting to examine the expression of inflammation associated miRNAs in the context of traumatic brain injury using a mouse controlled cortical impact model.

Wed Sep 30 00:00:00 UTC 2020

Signal Transducer and Activator of Transcription 1 (STAT1) Knock-down Induces Apoptosis in Malignant Pleural Mesothelioma.

Pathology oncology research : POR

Arzt L,Halbwedl I,Gogg-Kamerer M,Popper HH

385200 was used in immunohistochemistry - paraffin section and western blot to examine the oncogenic function of signal transducer and activator of transcription 1 in malignant pleural mesothelioma

Sat Jul 01 00:00:00 UTC 2017

1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Chen Y,Liu W,Sun T,Huang Y,Wang Y,Deb DK,Yoon D,Kong J,Thadhani R,Li YC

38-5200 was used in western blot to demonstrate that vitamin D receptor signaling attenuates TLR-mediated inflammation.

Mon Apr 01 00:00:00 UTC 2013

Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus.

PloS one

Hale MB,Krutzik PO,Samra SS,Crane JM,Nolan GP

Published figure using SOCS1 polyclonal antibody (Product # 38-5200) in Western Blot

Tue Aug 25 00:00:00 UTC 2009

Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus.

PloS one

Hale MB,Krutzik PO,Samra SS,Crane JM,Nolan GP

Published figure using SOCS1 polyclonal antibody (Product # 38-5200) in Western Blot

Tue Aug 25 00:00:00 UTC 2009

生物信息学

蛋白别名: cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; JAK2-binding protein; SOCS-1; SSI-1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP-3

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基因别名: CIS1; CISH1; Cish7; JAB; SOCS-1; SOCS1; SSI-1; SSI1; TIP3

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UniProt ID: (Human) O15524, (Mouse) O35716

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Entrez Gene ID: (Human) 8651, (Mouse) 12703

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功能

protein kinase inhibitor activity insulin-like growth factor receptor binding protein binding kinase inhibitor activity protein kinase binding kinase modulator

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