FIGURE: 1 / 2
Peptide Sequence: MTLDHQIINP TLKWSQPAVP SGGPLVQHAH TTLDSDAGLT ENPLTKLLAI GKEDDNAQWH LSGSILDVYS GEQGISPINM GLTSASCPS
This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein Aliases: bHLHe34; Class E basic helix-loop-helix protein 34; hTFEC-L; TFE-C; Transcription factor EC; Transcription factor EC-like
Gene Aliases: BHLHE34; hTFEC-L; TCFEC; TFE-C; TFEC; TFEC-L; TFECL
UniProt ID: (Human) O14948
Entrez Gene ID: (Human) 22797