Invitrogen

THRA/THRB Monoclonal Antibody (H43), APC

THRA/THRB Antibody in Immunocytochemistry (ICC/IF)

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THRA/THRB Antibody (MA5-45921) in ICC/IF

Immunocytochemistry/Immunofluorescence analysis using differentiated SH-SY5Y cells. Samples were incubated with Thyroid Hormone Receptor monoclonal antibody (Product # MA5-45921) at 1:250, followed by AlexaFluor 488. Counterstain used was phalloidin (Alexa 647, red), beta tubulin (Anti-beta III Tubulin Ab, Alexa 555, magenta) Hoechst (blue). (A) Phalloidin (B) Anti-beta III Tubulin Ab. (C) Thyroid Hormone R... View More

THRA/THRB Antibody in Immunohistochemistry (IHC)

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产品信息

MA5-45921

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500

免疫组化 (IHC)

1:100

免疫细胞化学 (ICC/IF)

1:250

酶联免疫吸附实验 (ELISA)

Assay-dependent

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

H43

抗原

Synthetic peptide from the full length Human Thyroid hormone receptor protein

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偶联物

APC APC APC

激发/发射光谱

651/660 nm 查看光谱

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

47.35mM phosphate/2.15mM MES, pH 7.4, with 2mM EDTA, 0.17066µM Pentachlorophenol, 0.8mM ethanol

内含物

no preservative

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2932375

产品详细信息

A 1:500 dilution of MA5-45921 was sufficient for detection of Pan-Thyroid hormone receptor in 10 µg of Hep G2 Human Hepatoblastoma Cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Detects 70 kDa.

靶标信息

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; c-erb-A thyroid hormone receptor; c-erbA-1; c-erbA-2; C-erbA-alpha; c-erbA-alpha2; c-erbA-beta; c-erbAalpha; c-erbAalpha2; EAR-7; ERBA-related 7; Nuclear receptor subfamily 1 group A member 1; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; THR; thyroid hormone nuclear receptor beta variant 1; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); Thyroid hormone receptor beta; thyroid hormone receptor beta 3; thyroid hormone receptor beta2delta; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); thyroid normone nuclear receptor alpha variant 1; TR alpha 1; TR alpha 2; TR beta; TRbeta2Delta; triiodothyronine receptor; V-erbA-related protein 7

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基因别名: 6430529J03Rik; AR7; AW259572; c-ERBA-1; C-ERBA-2; C-erba-alpha; C-ERBA-BETA; c-erbAbeta; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; ERBA2; GRTH; NR1A1; NR1A2; PRTH; RATT3REC; Rvr; T3R[a]; T3R[b]; T3Ralpha; T3Rbeta; T3rec; THR1; THRA; THRA1; THRA2; THRB; THRB1; THRB2; TRbeta