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Invitrogen
WNK4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-53437
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ISEEGKPQLV GRFQVTSSKE PAEPLPLQPT SPTLSGSPKP STPQLTSESS DTEDSAGGGP ETREALAESD RAAEGLGAGV EEEGDDGKEP QVGGSPQPLS HPSPVWMNYS YSSLCLSSEE SESSGEDEEF WAEL
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 87%.
靶标信息
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: protein kinase lysine-deficient 4; protein kinase with no lysine 4; RP23-281C18.8; unnamed protein product
基因别名: PHA2B; PRKWNK4
UniProt ID: (Human) Q96J92
Entrez Gene ID: (Human) 65266
response to dietary excess
renal sodium ion transport
protein phosphorylation
inflammatory response
signal transduction
regulation of blood pressure
response to xenobiotic stimulus
gene expression
negative regulation of sodium ion transport
cellular chloride ion homeostasis
intracellular signal transduction
sodium ion transmembrane transport
aldosterone secretion
macrophage activation
homeostatic process
ion homeostasis
calcium ion homeostasis
renal sodium ion absorption
ERK1 and ERK2 cascade
cellular response to xenobiotic stimulus
potassium ion transmembrane transport
distal tubule morphogenesis
negative regulation of protein localization to plasma membrane
regulation of potassium ion export across plasma membrane
response to aldosterone
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
