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Thyroid diseases and their impact
Thyroid diseases rank among the most frequent medical conditions, affecting individual patient wellbeing and imposing considerable costs on healthcare systems. Depending on iodine supply, or lack thereof, up to 50% of the total population experience an enlargement of the thyroid gland, also known as goiter. Nodular alterations are found in 5 to 25% of the population, with the frequency increasing in line with age.
Graves’ disease
Graves' disease is an autoimmune thyroid disease that is characterized by the clinical symptoms of goiter, tachycardia and exophthalmos (abnormal protrusion of the eyeballs). Graves' disease must be distinguished from the functional autonomy of the thyroid since the former can initially be treated by the application of drugs while the latter should be treated by surgery or radioiodine therapy. The measurement of the TSH receptor antibody concentration (TRAK) is key to detecting and adequately treating Graves' disease.
B·R·A·H·M·S TRAK human KRYPTOR: A tool of choice in Graves' disease diagnostics
With high sensitivity, specificity, and excellent clinical applicability Thermo Scientific B·R·A·H·M·S TRAK human KRYPTOR Assay is the tool of choice in differential diagnosis and follow-up in Graves’ disease addressing critical clinical questions.
Hashimoto’s thyroiditis
Hashimoto's thyroiditis is another autoimmune disease of the thyroid gland in which the destruction of thyroid tissue ultimately causes hypothyroidism characterized by a multitude of metabolic symptoms. For Hashimoto’s disease, the presence of autoantibodies against thyroid proteins is characteristic, and the most prominent targets are TPO and - to a lesser extent - also thyroglobulin (Tg).
B·R·A·H·M·S anti-TPOn KRYPTOR and anti-Tgn KRYPTOR Assays
The severity of Hashimoto’s thyroiditis can be assessed with the help of Thermo Scientific B·R·A·H·M·S anti-TPOn and Thermo Scientific B·R·A·H·M·S anti-Tgn Assays. Due to the use of native assay components, both assays achieve improved analytical sensitivity and specificity.
Thyroid cancer
Carcinomas of the thyroid account for 0.5 to 1.54.6% of all prevalent cancerous diseases (1-year prevalence). In 80% of all cases, these are differentiated thyroid carcinomas with a relatively good prognosis, provided the disease is diagnosed at an early stage and carefully followed up.
Differential thyroid carcinoma (DTC) is the most common endocrine cancer worldwide. Initial treatment for this disease consists of total thyroidectomy usually followed by ablation of thyroid remnant with radioiodine. To reliably and effectively monitor patients for recurrent or persistent disease, circulating thyroglobulin (hTg) is used as a biochemical marker. As thyroid cells are the only source of hTg, it is highly specific for DTC and recommended for use as a biomarker by the international clinical practice guidelines.
Confident follow-up of thyroid cancer patients with B·R·A·H·M·S hTg sensitive KRYPTOR
Our Thermo Scientific B·R·A·H·M·S hTg sensitive KRYPTOR Assay enables laboratories to measure hTg concentrations with excellent sensitivity and accuracy, helping to ensure efficiency and effectiveness.
Experience the benefits of the KRYPTOR Analyzer in your lab
Thermo Scientific B·R·A·H·M·S KRYPTOR Analyzers are fully automated random-access benchtop immunoanalyzers that use Nobel prize winning TRACE technology to ensure fast and reliable test results for essential indications.
- Drive uncompromised quality to support safe patient management.
- Easy and straightforward laboratory routine with less operator intervention
- Self-determining dilution factor (SDDF) & auto dilutions greatly reduce sample re-runs & eliminate hands-on time
- Environmentally friendly design that produces less material waste
Only KRYPTOR compact PLUS is available for sale in the US.
Explore the B·R·A·H·M·S portfolio of diagnostic tests for thyroid disease
Confident follow-up of thyroid cancer patients with B·R·A·H·M·S hTg sensitive KRYPTOR
Our B·R·A·H·M·S hTg sensitive KRYPTOR assay enables laboratories to measure hTg concentrations with excellent sensitivity and accuracy, helping to ensure efficiency and effectiveness.
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