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Complement-dependent Cytotoxicity (CDC) for HLA, Episode 1
The first episode of the 2026 Back to Basics series provides a comprehensive overview of the Complement-Dependent Cytotoxicity (CDC) assay and its application in HLA testing. The session reviews the scientific principles underlying CDC, including complement activation and cell lysis, and outlines the key procedural steps involved in performing the assay. It also explores the role of CDC in antibody detection and crossmatch testing, emphasizing its importance in assessing donor-recipient compatibility. The presentation highlights practical considerations, interpretation of results, and the role of CDC as a foundational method in HLA laboratories.
Instructor:
James Jones, MSc, BSHIdip,
Sr. Technical Training Specialist – Antibody, Thermo Fisher Scientific
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