The Benefits of an Optimized Peptone Mix for Veterinary Vaccine Fermentation

Your peptone mix is critical for maximizing vaccine yield and quality.

Small changes in selection may lead to significant impacts on performance – don't leave your peptone mix to chance.

Why your peptone mix matters

In veterinary vaccine production, even small variations in your peptone mix can lead to significant differences in both yield and consistency. Peptones are biologically derived, meaning each batch can subtly affect the growth of fastidious and non-fastidious organisms. For veterinary vaccines, this can make or break your production goals – from production efficiency to the quality of your final product.

5 considerations and questions to ask when selecting your peptone mix

Whether you’re just beginning your vaccine development or still in the planning stages, understanding how peptone variability affects your work is critical. 

 

An optimized peptone mix can make all the difference in the success of your vet vaccine. 

The benefits of an optimal peptone mix

Helps maximize yield efficiency

An optimized peptone mix provides essential nutrients, ensuring robust microbial growth and higher vaccine yields. It can also help reduce variability in production, leading to more reliable batch-to-batch performance.

Consistent vaccine quality

Peptones with the right balance of nitrogen and other key nutrients can help support predictable cell growth, reducing fluctuations that can compromise vaccine quality. Consistency in your peptone mix helps maintain potency and stability in your final product.

Helps reduce downtime and rework

Inefficiencies or inconsistencies in your peptone mix may lead to batch failures or require rework, costing time and resources. Help maintain a smooth and interrupted production process with a reliable peptone mix. 

Improved process scalability

As your production increases, so do the demands of your fermentation process. An optimized peptone mix can help you replicate success at larger scales, with reliable results across all production sizes.

Ensure your new vaccine is supported with the optimal peptone mix from the beginning. Schedule a consultation to meet one-on-one with one of our experienced R&D team members. 

Understanding peptone types and their role in veterinary vaccine development

Animal-Derived Peptones

Sourced from animal tissues like meat and organs, these peptones are nutrient-rich, particularly in nitrogen, and often preferred for fastidious organisms.

 

Pros: 

  • Rich nutrient profile with a wide range of amino acids and growth factors
  • Well established in fermentation processes
  • May be lower in cost than animal-origin-free peptones

 

Cons:

  • Higher risk of contamination from animal sources (e.g. BSE)
  • Higher regulatory scrutiny

Plant-Derived Peptones

Made from soy, wheat, or other plant materials, these peptones offer greater consistency and lower contamination risk.

 

Pros: 

  • Lower risk of contamination (Bovine spongiform encephalopathy [BSE]) 
  • May support regulatory compliance for reduced animal origin content
  • Production can be more sustainable vs animal origin

 

Cons:

  • May offer a limited nutritional profile
  • Possible requirement of supplementation with additional growth factors 

For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.