The ability to accurately and effectively identify and validate your target of interest is a critical step in your drug discovery and development journey. At Thermo Fisher Scientific, we have designed award winning siRNA and CRISPR libraries for High Throughput Screening to interrogate functional pathways, proliferation, gene expression analysis, and protein modifications.
To take full advantage of the potential functional genomics screen present to your drug discovery projects, we now offer both siRNA and CRISPR libraries screening services.
At Thermo Fisher Scientific, we have applied the power of the CRISPR-Cas9 system to high throughput screening applications with our award winning pooled and arrayed CRISPR libraries.
Using this next generation tool for functional genomics screening, a complete and permanent knockout of gene expression can be achieved. Our LentiArray Human CRISPR libraries are organized by gene family and/or function.
Validating novel targets or a wide-range of targets is challenged by the lack of known small molecule inhibitors for each target. The use of RNA interference utilizing siRNAs provides a unique solution to this problem. Superior siRNAs for in vitro RNAi applications is the best way to effectively knock down gene expression to study protein function in a wide range of cell types.
With our siRNA screening service, we can address a broader number of targets and achieves specificity through target-specific knockdown. Adding siRNA screening to your early drug discovery screening programs can help to identify targets that traditional biochemical and cell-based screening and profiling may miss.
Upon receipt of your initial inquiry, a dedicated project manager is assigned to your project to streamline communication throughout your project. Once the project requirements have been finalized by both parties, our functional genomics screening process begins – with project steps summarized below.
“The LentiArray CRISPR libraries have allowed us to make significant inroads in our research on pediatric cancer, discovering a potentially novel strategy for the treatment of deadly brain tumors,” said Simone Treiger Sredni M.D., Ph.D., associate professor of pediatric neurosurgery at Northwestern University Feinberg School of Medicine. “Through the use of lenti-viral CRISPR-Cas9 particles, we identified an enzyme that can be inhibited by drugs and has been shown to prohibit tumor cell growth without affecting normal cells.”
With many labs facing resources restraints, our Custom Biology team offers institutions a powerful resource to extend their research teams. Wholly dedicated to developing custom tools and assays, the team has the expertise to select an assay technology from the extensive Thermo Fisher Scientific toolbox and use these technologies to craft tools that meet your unique requirements.
From your initial inquiry through every milestone of your project, you can expect exceptional service and frequent, proactive communication from a dedicated project manager. Your project manager will help ensure all parties involved in the project are aligned on project requirements, timelines and budgets.