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精准医学蛋白质组学图书馆
A draft map of the human proteome (Nature, 2014, 509: 575)（人类蛋白质组草图）
Advancing Urinary Protein Biomarker Discovery by Data-Independent Acquisition on a Quadrupole-Orbitrap Mass Spectrometer (J Proteome Res, 2015, 14: 4752)（尿液）
Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells (Nat Chem Biol, 2012, 8: 486)（腺花素作用靶点研究）
Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma (Clin Cancer Res, 2015, 21: 3512)（尿液 – 胰腺癌早期诊断）
Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer (Cell, 2016, 166: 755)（卵巢癌蛋白基因组分析）
Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling (Cell, 2015, 163: 202)（激酶组蛋白基因组分析）
Mass-spectrometry-based draft of the human proteome (Nature, 2014, 509: 582)（人类蛋白质组草图）
Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury (Molecular & Cellular Proteomics, 2015, 14: 2375)（血液 – 心肌损伤早期诊断）
Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation (Mol Cell Proteomics, 2015, 14: 658)（人免疫肽组学研究）
Plasma Proteome Profiling to Assess Human Health and Disease (Cell Systems, 2016, 2: 185)（临床快速诊断流程）
Proteomic workflow for analysis of archival formalin-fixed and paraffin-embedded clinical samples to a depth of 10 000 proteins (Proteomics Clin Appl, 2013, 7: 225)（石蜡包埋）
Proteogenomics connects somatic mutations to signalling in breast cancer (Nature, 2016, 534: 55)（乳腺癌蛋白基因组分析）
Proteogenomics: Integrating Proteomics and Genomics to Unlock Biological Function
The One Hour Yeast Proteome (Mol Cell Proteomics, 2014, 13: 339)（一小时蛋白质组）
The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapy (Blood, 2015, 126: 1203)（T细胞治疗潜在靶标发现）
A draft map of the human proteome (Nature, 2014, 509: 575)（人类蛋白质组草图）
Advancing Urinary Protein Biomarker Discovery by Data-Independent Acquisition on a Quadrupole-Orbitrap Mass Spectrometer (J Proteome Res, 2015, 14: 4752)（尿液）
Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells (Nat Chem Biol, 2012, 8: 486)（腺花素作用靶点研究）
Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma (Clin Cancer Res, 2015, 21: 3512)（尿液 – 胰腺癌早期诊断）
Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer (Cell, 2016, 166: 755)（卵巢癌蛋白基因组分析）
Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling (Cell, 2015, 163: 202)（激酶组蛋白基因组分析）
Mass-spectrometry-based draft of the human proteome (Nature, 2014, 509: 582)（人类蛋白质组草图）
Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury (Molecular & Cellular Proteomics, 2015, 14: 2375)（血液 – 心肌损伤早期诊断）
Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation (Mol Cell Proteomics, 2015, 14: 658)（人免疫肽组学研究）
Plasma Proteome Profiling to Assess Human Health and Disease (Cell Systems, 2016, 2: 185)（临床快速诊断流程）
Proteomic workflow for analysis of archival formalin-fixed and paraffin-embedded clinical samples to a depth of 10 000 proteins (Proteomics Clin Appl, 2013, 7: 225)（石蜡包埋）
Proteogenomics connects somatic mutations to signalling in breast cancer (Nature, 2016, 534: 55)（乳腺癌蛋白基因组分析）
Proteogenomics: Integrating Proteomics and Genomics to Unlock Biological Function
The One Hour Yeast Proteome (Mol Cell Proteomics, 2014, 13: 339)（一小时蛋白质组）
The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapy (Blood, 2015, 126: 1203)（T细胞治疗潜在靶标发现）
高通量定量蛋白质组技术（TMT）从样品制备、仪器分析、到数据分析全流程
内标掺入 SILAC 法用于小量组织的蛋白质组及磷酸化蛋白质组定量
Q Exactive HF一小时DDA鉴定DIA定量4000个Hela蛋白
Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation (Mol Cell Proteomics, 2015, 14: 658)
Proteogenomics connects somatic mutations to signalling in breast cancer (Nature, 2016, 534: 55)
Revolutionizing Data Independent Acquisition on q-OT-IT Tribrid Mass Spectrometers
Targeted Kinase Inhibitor Profiling Using a Hybrid Quadrupole-Orbitrap Mass Spectrometer
蛋白质组学向临床诊断的转化
Dr. Eleftherios P. Diamandis, MD, PhD, FRCP(C) with Mount Sinai Hospital, Dept. of Pathology & Laboratory Medicine & the Lunefel-Tanenbaum Research Institute
基于超高分辨质谱的精准医学研究
李静，大分子应用经理，生命科学质谱，赛默飞世尔科技
生命科学质谱在精准医疗中的应用
唐家澍 博士，应用工程师，生命科学质谱，赛默飞世尔科技
赛默飞多组学整合解决方案
不知道蛋白基因组到底咋回事？多组学整合这么热，到底咋整？赛默飞质谱应用工程师周岳为您解答，告诉您蛋白质组与基因组、代谢组的整合流程和实际案例。
Translational proteomics: From one-by-one to all-in-one clinical assays
Irene van den Broek, PhD, Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles
外泌体蛋白质组：HTLV-1病毒的白血病致病机理与标志物研究
Dr. Sucharita Dutta, Senior Research Associate at the Eastern Virginia Medical School
以精准医学为导向的靶向蛋白质组学研究：
上海交通大学严威教授团队，使用样本数字化DIA技术和靶向蛋白质组PRM技术，在疾病研究和临床转化方面做了诸多前沿工作。尤其是与多家医院合作，利用数百例非小细胞肺癌病人的血液，分离其中单个核细胞，进行高通量DIA分析，发现了十多种蛋白存在显著表达差异。基于该发现，严威教授团队正在开发肺结节良恶性判断的标志物集，并应用于实际临床诊断。
A draft map of the human proteome (Nature, 2014, 509: 575)（人类蛋白质组草图）
Advancing Urinary Protein Biomarker Discovery by Data-Independent Acquisition on a Quadrupole-Orbitrap Mass Spectrometer (J Proteome Res, 2015, 14: 4752)（尿液）
Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells (Nat Chem Biol, 2012, 8: 486)（腺花素作用靶点研究）
Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma (Clin Cancer Res, 2015, 21: 3512)（尿液 – 胰腺癌早期诊断）
Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer (Cell, 2016, 166: 755)（卵巢癌蛋白基因组分析）
Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling (Cell, 2015, 163: 202)（激酶组蛋白基因组分析）
Mass-spectrometry-based draft of the human proteome (Nature, 2014, 509: 582)（人类蛋白质组草图）
Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury (Molecular & Cellular Proteomics, 2015, 14: 2375)（血液 – 心肌损伤早期诊断）
Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation (Mol Cell Proteomics, 2015, 14: 658)（人免疫肽组学研究）
Plasma Proteome Profiling to Assess Human Health and Disease (Cell Systems, 2016, 2: 185)（临床快速诊断流程）
Proteomic workflow for analysis of archival formalin-fixed and paraffin-embedded clinical samples to a depth of 10 000 proteins (Proteomics Clin Appl, 2013, 7: 225)（石蜡包埋）
Proteogenomics connects somatic mutations to signalling in breast cancer (Nature, 2016, 534: 55)（乳腺癌蛋白基因组分析）
Proteogenomics: Integrating Proteomics and Genomics to Unlock Biological Function
The One Hour Yeast Proteome (Mol Cell Proteomics, 2014, 13: 339)（一小时蛋白质组）
The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapy (Blood, 2015, 126: 1203)（T细胞治疗潜在靶标发现）
A draft map of the human proteome (Nature, 2014, 509: 575)（人类蛋白质组草图）
Advancing Urinary Protein Biomarker Discovery by Data-Independent Acquisition on a Quadrupole-Orbitrap Mass Spectrometer (J Proteome Res, 2015, 14: 4752)（尿液）
Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells (Nat Chem Biol, 2012, 8: 486)（腺花素作用靶点研究）
Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma (Clin Cancer Res, 2015, 21: 3512)（尿液 – 胰腺癌早期诊断）
Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer (Cell, 2016, 166: 755)（卵巢癌蛋白基因组分析）
Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling (Cell, 2015, 163: 202)（激酶组蛋白基因组分析）
Mass-spectrometry-based draft of the human proteome (Nature, 2014, 509: 582)（人类蛋白质组草图）
Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury (Molecular & Cellular Proteomics, 2015, 14: 2375)（血液 – 心肌损伤早期诊断）
Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation (Mol Cell Proteomics, 2015, 14: 658)（人免疫肽组学研究）
Plasma Proteome Profiling to Assess Human Health and Disease (Cell Systems, 2016, 2: 185)（临床快速诊断流程）
Proteomic workflow for analysis of archival formalin-fixed and paraffin-embedded clinical samples to a depth of 10 000 proteins (Proteomics Clin Appl, 2013, 7: 225)（石蜡包埋）
Proteogenomics connects somatic mutations to signalling in breast cancer (Nature, 2016, 534: 55)（乳腺癌蛋白基因组分析）
Proteogenomics: Integrating Proteomics and Genomics to Unlock Biological Function
The One Hour Yeast Proteome (Mol Cell Proteomics, 2014, 13: 339)（一小时蛋白质组）
The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapy (Blood, 2015, 126: 1203)（T细胞治疗潜在靶标发现）
高通量定量蛋白质组技术（TMT）从样品制备、仪器分析、到数据分析全流程
内标掺入 SILAC 法用于小量组织的蛋白质组及磷酸化蛋白质组定量
Q Exactive HF一小时DDA鉴定DIA定量4000个Hela蛋白
Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation (Mol Cell Proteomics, 2015, 14: 658)
Proteogenomics connects somatic mutations to signalling in breast cancer (Nature, 2016, 534: 55)
Revolutionizing Data Independent Acquisition on q-OT-IT Tribrid Mass Spectrometers
Targeted Kinase Inhibitor Profiling Using a Hybrid Quadrupole-Orbitrap Mass Spectrometer
蛋白质组学向临床诊断的转化
Dr. Eleftherios P. Diamandis, MD, PhD, FRCP(C) with Mount Sinai Hospital, Dept. of Pathology & Laboratory Medicine & the Lunefel-Tanenbaum Research Institute
基于超高分辨质谱的精准医学研究
李静，大分子应用经理，生命科学质谱，赛默飞世尔科技
生命科学质谱在精准医疗中的应用
唐家澍 博士，应用工程师，生命科学质谱，赛默飞世尔科技
赛默飞多组学整合解决方案
不知道蛋白基因组到底咋回事？多组学整合这么热，到底咋整？赛默飞质谱应用工程师周岳为您解答，告诉您蛋白质组与基因组、代谢组的整合流程和实际案例。
Translational proteomics: From one-by-one to all-in-one clinical assays
Irene van den Broek, PhD, Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles
外泌体蛋白质组：HTLV-1病毒的白血病致病机理与标志物研究
Dr. Sucharita Dutta, Senior Research Associate at the Eastern Virginia Medical School
以精准医学为导向的靶向蛋白质组学研究：
上海交通大学严威教授团队，使用样本数字化DIA技术和靶向蛋白质组PRM技术，在疾病研究和临床转化方面做了诸多前沿工作。尤其是与多家医院合作，利用数百例非小细胞肺癌病人的血液，分离其中单个核细胞，进行高通量DIA分析，发现了十多种蛋白存在显著表达差异。基于该发现，严威教授团队正在开发肺结节良恶性判断的标志物集，并应用于实际临床诊断。